Table 4

Allele frequencies of GNB1 single nucleotide polymorphisms in HCV-1 and HCV-2 infected patients receiving PEG-IFNα-RBV therapy with and without a RVR in a Chinese population in Taiwan
HCV-1 HCV-2
SNP ID RVR (+) (N = 108) N (%) RVR (−) (N = 157) N (%) Pvalue OR (95% CI) SNP ID RVR (+) (N = 158) N (%) RVR (−) (N = 37) N (%) Pvalue OR (95% CI)
rs10907185 rs10907185
A allele 65 (30.0) 80 (25.5) 1.26 (0.86, 1.85) A allele 88 (27.8) 16 (21.6) 1.40 (0.76, 2.56)
G allele 151 (70.0) 234 (74.5) 0.2416 1 G allele 228 (72.2) 58 (78.4) 0.2756 1
rs6603797 rs6603797
C allele 193 (89.4) 270 (86.0) 1.37 (0.80, 2.34) C allele 285 (90.2) 67 (90.5) 0.96 (0.41, 2.28)
T allele 23 (10.6) 44 (14.0) 0.2521 1 T allele 31 (9.8) 7 (9.5) 0.9270 1
rs4648727a rs4648727a
A allele 70 (32.4) 107 (34.3) 0.92 (0.64, 1.33) A allele 111 (35.1) 17 (23.6) 1.75 (0.97, 3.16)
C allele 146 (67.6) 205 (65.7) 0.6515 1 C allele 205 (64.9) 55 (76.4) 0.0607 1
rs12126768a rs12126768
G allele 45 (20.8) 86 (27.6) 0.69 (0.46, 1.04) G allele 75 (23.7) 16 (21.6) 1.13 (0.61, 2.08)
T allele 171 (79.2) 226 (72.4) 0.0783 1 T allele 241 (76.3) 58 (78.4) 0.6989 1

a: Contains 1 missing data point in the RVR (−) group.

Abbreviations: SNP, single nucleotide polymorphism; RVR, rapid virological response; OR, odds ratio; CI, confidence interval.

Allele frequencies were determined by χ2 test using 2 × 2 tables. Odds ratios and 95% CI per allele were estimated by unconditional logistic regression. P values less than 0.05 were considered statistically significant.

Lim et al.

Lim et al. BMC Gastroenterology 2012 12:167   doi:10.1186/1471-230X-12-167

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