Table 3

Genotype frequencies of GNB1 single nucleotide polymorphisms (SNPs) in HCV-1 and HCV-2 infected patients receiving PEG-IFNα-RBV therapy with and without a RVR in a Chinese population in Taiwan
HCV-1 HCV-2
SNP ID RVR (+) (N = 108) N (%) RVR (−) (N = 157) N (%) Pvalue OR (95% CI) SNP ID RVR (+) (N = 158) N (%) RVR (−) (N = 37) N (%) Pvalue OR (95% CI)
rs10907185 rs10907185
A/A 10 (9.2) 5 (3.2) 3.09 (1.00, 9.56) A/A 13 (8.3) 3 (8.1) 1.25 (0.33, 4.76)
A/G 45 (41.7) 70 (44.6) 0.99 (0.60, 1.66) A/G 62 (39.2) 10 (27.0) 1.79 (0.80, 4.02)
G/G 53 (49.1) 82 (52.2) 0.1096 1 G/G 83 (52.5) 24 (64.9) 0.3601 1
A/A + A/G 55 (50.9) 75 (47.8) 0.6137 1.13 (0.69, 1.85) A/A + A/G 75 (47.5) 13 (35.1) 0.1748 1.67 (0.79, 3.51)
rs6603797 rs6603797
C/C 87 (80.5) 116 (73.9) 1.13 (0.18, 6.88) C/C 129 (81.6) 31 (83.8) 2.08 (0.18, 23.69)
C/T 19 (17.6) 38 (24.2) 0.75 (0.12, 4.88) C/T 27 (17.1) 5 (13.5) 2.70 (0.20, 35.75)
T/T 2 (1.9) 3 (1.9) 0.4332 1 T/T 2 (1.3) 1 (2.7) 0.7216 1
C/C + C/T 106 (98.1) 154 (98.1) 0.9723 1.03 (0.17, 6.29) C/C + C/T 156 (98.7) 36 (97.3) 0.5227 2.17 (0.19, 24.55)
rs4648727a rs4648727a
A/A 10 (9.3) 14 (9.0) 0.94 (0.38, 2.29) A/A 16 (10.1) 4 (11.1) 1.46 (0.44, 4.83)
A/C 50 (46.3) 79 (50.6) 0.83 (0.50, 1.39) A/C 79 (50.0) 9 (25.0) 3.20 (1.39, 7.41)
C/C 48 (44.4) 63 (40.4) 0.7779 1 C/C 63 (39.9) 23 (63.9) 0.0194* 1
A/A + A/C 60 (55.6) 93 (59.6) 0.5112 0.86 (0.52, 1.41) A/A + A/C 95 (60.1) 13 (36.1) 0.0089* 2.67 (1.26, 5.65)
rs12126768a rs12126768
G/G 6 (5.5) 9 (5.8) 0.76 (0.26, 2.25) G/G 6 (3.8) 4 (10.8) 0.42 (0.11, 1.61)
G/T 33 (30.6) 68 (43.6) 0.56 (0.33, 0.94) G/T 63 (39.9) 8 (21.6) 2.21 (0.94, 5.22)
T/T 69 (63.9) 79 (50.6) 0.0891 1 T/T 89 (56.3) 25 (67.6) 0.0436* 1
G/G + G/T 39 (36.1) 77 (49.4) 0.0330* 0.58 (0.35, 0.96) G/G + G/T 69 (43.7) 12 (32.4) 0.2118 1.62 (0.76, 3.44)

a: Contains 1 missing data point in the RVR (−) group.

Abbreviations: SNP, single nucleotide polymorphism; RVR, rapid virological response; OR, odds ratio; CI, confidence interval.

Genotype frequencies were determined by χ2 test using 2 × 3 or 2 × 2 tables as appropriate. Odds ratios and 95% CI per genotype were estimated by unconditional logistic regression. P values less than 0.05 were considered statistically significant, and are denoted with an asterisk.

Lim et al.

Lim et al. BMC Gastroenterology 2012 12:167   doi:10.1186/1471-230X-12-167

Open Data