Email updates

Keep up to date with the latest news and content from BMC Gastroenterology and BioMed Central.

Open Access Research article

Association of genetic variations in GNB1 with response to peginterferon plus ribavirin therapy for chronic hepatitis C in a Chinese population in Taiwan

Yun-Ping Lim12, Fuu-Jen Tsai345, Wen-Ling Liao6, Ni Tien789, Dong-Zong Hung12, Cheng-Yuan Peng1011* and Lei Wan1234*

Author affiliations

1 Department of Pharmacy, College of Pharmacy, China Medical University, Taichung, 40402, Taiwan

2 Department of Emergency, Toxicology Center, China Medical University Hospital, Taichung, 40447, Taiwan

3 School of Chinese Medicine, China Medical University, Taichung, 40402, Taiwan

4 Genetic Center, China Medical University Hospital, Taichung, 40447, Taiwan

5 Department of Pediatrics, China Medical University Hospital, Taichung, 40447, Taiwan

6 Center for Personalized Medicine, China Medical University Hospital, Taichung, 40447, Taiwan

7 Department of Laboratory Medicine, China Medical University Hospital, Taichung, 40447, Taiwan

8 Department of Veterinary Medicine, National Chung Hsing University, Taichung, 40227, Taiwan

9 Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, 40402, Taiwan

10 Department of Internal Medicine, China Medical University, Taichung, 40402, Taiwan

11 Department of Internal Medicine, Division of Digestive System and Gastroenterology, China Medical University Hospital, Taichung, 40447, Taiwan

12 Department of Health and Nutrition Biotechnology, Asia University, Taichung, 41354, Taiwan

For all author emails, please log on.

Citation and License

BMC Gastroenterology 2012, 12:167  doi:10.1186/1471-230X-12-167

Published: 22 November 2012

Abstract

Background

The aim of this study was to evaluate whether polymorphisms in the guanine nucleotide binding (G protein), beta polypeptide 1 (GNB1) gene are associated with a rapid virological response (RVR) among HCV genotype 1 (HCV-1) and 2 (HCV-2) infected patients receiving peginterferon plus ribavirin treatment (PEG-IFNα-RBV).

Methods

We analyzed the association between RVR to PEG-IFNα-RBV therapy and 4 tagging single nucleotide polymorphisms (SNPs) of the GNB1 gene. This study included 265 HCV-1 and 195 HCV-2 infected patients in a Chinese population in Taiwan.

Results

Among the GNB1 SNPs examined, the combination of genotypes G/G and G/T populations of rs12126768 was significant inversely correlated with RVR in HCV-1 infected patients (P = 0.0330), whereas HCV-2 infected patients, combination of A/A and A/C genotypes populations at rs4648727 responded better to the PEG-IFNα-RBV treatment (P = 0.0089). However, there were no significant differences in the allele frequencies of those SNPs between RVR responders and non-responders. Several RVR susceptibility GNB1 haplotypes were identified, and the ACAT haplotype of the 4 SNPs may increase the successful outcomes of HCV-1 and HCV-2 infected patients (P = 0.0261 and P = 0.0253, respectively).

Conclusion

The data for GNB1 SNPs and the association of RVR showed that GNB1 polymorphisms might be associated with the therapeutic outcomes of HCV-1 and HCV-2 infected patients under standard of care (SOC) treatment.

Keywords:
Hepatitis C virus; Standard of care treatment; Rapid virological response; G protein