Table 1

Characteristics of the different groups in the spectrum of coeliac disease
SPECTRUM OF CD
ACD GFD RCDI RCDII EATL
(n = 26) (n = 26) (n = 12) (n = 16) (n = 12)
Age at CD (yr) Median, (SD;range) 42.5 45 50.5 61.5 61.5
(16; 21-76) ( 15; 21-77) (16; 19-69) (13; 27-74) (7; 48-66)
Age at RCD Median, (SD;range) - - 59 65 64
(11.5; 35-74) (10; 47-77) (8; 51-72)
Age at EATL Median, (SD;range) - - - - 65
(6; 51-74)
HLA-staus DQ2 heterozygous 10 7 8 7 3
DQ8 heterozygous 9 13 3
DQ2/8 heterozygous 3 2 1 3 2
DQ2 homozygous 4 4 3 6 4
Marsh 0 12 2
I 4
II 1
IIIA 11 8 9 5
IIIB 5 3 4 3
IIIC 10 1 3 1
ND 10
EMA Negative (-) 26 12 15 7
Dubious (+/-) 1 2
Weak positive (+) 3
Positive (++) 11 0
Stronglypositive(+++) 11 2
ND 1 1
TGA Negative 7 12 14 6
Dubious 2 2
Weak positive 8 1
Positive 6 1
Strongly positive 9 1
ND 3 19 1
Aberrant IELs (%) Mean (SD;range) - - 4,0 64 7
(6.0; 2-19) (23; 20-96) (32; 1-87)
EATL type Primary - - - - 4
Secondary 8

ACD: active coeliac disease patients; GFD: coeliac disease patients on a gluten-free diet; RCDI and II: refractory coeliac disease type I and II; EATL: enteropathy associated T-cell lymphoma; EMA-A: endomysial antibodies; tTGA-A: tissue transglutaminase antibodies; IELs: intra-epithelial lymphocytes.

Tack et al.

Tack et al. BMC Gastroenterology 2012 12:159   doi:10.1186/1471-230X-12-159

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