Table 1

Data Among HCV-positive patients who underwent splenectomy (Spx group) and who did not (non-Spx group)
Spx group (n=37) Non-Spx group (n=90) P value
Age (y), mean ± SD 58 ±1 61 ± 1 n.s
Sex (male / female), n 19 / 18 44 / 46 n.s
Body Mass Index (kg/m2), mean ± SD 24.9 ± 0.5 22.7 ± 0.5 0.002
Hemoglobin level (g/dl), mean ± SD 12.5 ± 0.3 13.2 ± 0.2 0.03
Platelet count (x104/μl), mean ± SD 5.9 ± 0.2 8.7 ± 0.2 <0.0001
Alanine aminotransferase level (IU/L), mean ± SD 55 ± 10 91 ± 7.9 0.001
Gamma-glutamyle transpeptidase (IU/L), mean ± SD 45 ± 7.4 60 ± 5.1 0.02
Albumin level (g/dl), mean ± SD 3.3 ± 0.07 3.9 ± 0.06 <0.0001
Pretreatment viral load (logIU/mL), mean ± SD 5.9 ± 0.1 6.2 ± 0.1 n.s
HCV genotype (1/2), n 32 / 5 69 / 21 n.s
IL28B genotype (major/minor), n 26 / 11 62 / 28 n.s
ITPA genotype (major/minor), n 26 / 11 61 / 29 n.s

HCV; hepatitis C virus, IL28B; interleukin-28B, ITPA; inosine triphosphate pyrophosphatase, n.s ; not significant.

Spx; splenectomy.

Motomura et al.

Motomura et al. BMC Gastroenterology 2012 12:158   doi:10.1186/1471-230X-12-158

Open Data