Email updates

Keep up to date with the latest news and content from BMC Gastroenterology and BioMed Central.

Open Access Study protocol

The value of pancreatic stone protein in predicting acute appendicitis in patients presenting at the emergency department with abdominal pain

Christoph Tschuor*, Dimitri Aristotle Raptis, Përparim Limani, Thomas Bächler, Christian Eugen Oberkofler, Stefan Breitenstein and Rolf Graf

Author affiliations

Department of Surgery, University Hospital Zurich, Raemistrasse 100, Zurich, CH-8091, Switzerland

For all author emails, please log on.

Citation and License

BMC Gastroenterology 2012, 12:154  doi:10.1186/1471-230X-12-154

Published: 25 October 2012

Abstract

Background

Pancreatic Stone Protein (PSP) is a protein naturally produced mainly in the pancreas and the gut. There is evidence from experimental and clinical trials that blood PSP levels rise in the presence of inflammation or infection. However, it is not known whether PSP is superior to other established blood tests (e.g. White Blood Count, Neutrophils or C - reactive protein) in predicting appendicitis in patients presenting with abdominal pain and a clinical suspicion of appendicitis at the emergency room.

Methods/design

The PSP Appendix Trial is a prospective, multi-center, cohort study to assess the value of PSP in the diagnostic workup of acute appendicitis. 245 patients will be prospectively recruited. Interim analysis will be performed once 123 patients are recruited. The primary endpoint of the study concerns the diagnostic accuracy of PSP in predicting acute appendicitis and therefore the evidence of appendicitis on the histopathological specimen after appendectomy.

Discussion

The PSP Appendix Trial is a prospective, multi-center, cohort study to assess the value of PSP in the diagnostic workup of acute appendicitis.

Trial registration

ClinicalTrials.gov: NCT01610193; Institution Ethical Board Approval ID: KEKZH- Nr. 2011–0501

Keywords:
PSP; Pancreatic stone protein; Acute appendicitis; Abdominal pain