RvD1 inhibits cytokine expressions revealed by real-time PCR (A) and ELISA (B). Changes of TNF-alpha, IL-1beta, and IL-6 at mRNA and protein levels were determined in the T10 region of the dorsal spinal cord of CP or sham rats. Data are expressed as fold changes of naïve control group. TNBS infusion induced a remarkable increase of TNF-alpha, IL-1beta, and IL-6 compared with those of naïve groups. In addition, RvD1 could significantly decrease those expressions. *, # P<0.05 compared to sham-vehicle or TNBS-vehicle group, respectively.
Quan-Xin et al. BMC Gastroenterology 2012 12:148 doi:10.1186/1471-230X-12-148