Intrathecal administration of resolvin D 1 (RvD1) attenuates mechanical allodynia induced by CP. (A) Response frequencies to mechanical stimulation of the abdomen with the 40.7 mN of von-Frey filaments at different time points after RvD1 (or vehicle) administration. BL: baseline. (B) Response frequencies to mechanical stimulation of the abdomen with von-Frey filaments of various strengths at 4 h after RvD1 (or vehicle) treatments. *, # P<0.05 compared with that of sham-vehicle or TNBS-vehicle group, respectively. (C) TNBS-induced allodynia was significantly attenuated by RvD1 in a dose-dependent manner. * P<0.05 compared to 100 ng/kg group.
Quan-Xin et al. BMC Gastroenterology 2012 12:148 doi:10.1186/1471-230X-12-148