Table 6

Clinical features of 261 CHC patients from Northern Italy according to thePNPLA3I148M genotype
PNPLA3genotype CC n = 133 (51) CG n = 103 (39) GG n = 25 (10) p value
Age (years) 57±14 59±14 57±14 0.47
Sex (F) 58 (44) 46 (45) 6 (24) 0.16
BMI (Kg/m2) 25.2±3.4 25.3±3.9 26.6±6.1 0.25
ALT (IU/ml) 72±56 67±58 73±78 0.81
Diabetes 26 (20) 17 (17) 4 (16) 0.80
Insulin (IU/ml) 21 {14–27} 20 {17–27} 17 {12–25} 0.61
Glucose 95±22 96±26 93±22 0.85
Total cholesterol (mg/dl) 176±36 177±41 178±41 0.95
HDL cholesterol (mg/dl) 50±15 51±18 48±15 0.66
Triglycerides (mg/dl) 108±43 104±61 88±31* 0.24
HOMA-IR 4.7 {3.2-5.8} 4.5 {3.4-6.6} 3.8 {2.3-6.5} 0.62
Adiponectin (μg/ml) 9.3 {5.8-13} 9.4 {5.7-14} 9.7 {5.3-13} 0.93
Steatosis 85 (64) 72 (70) 22 (88) 0.02
Severe steatosis (> 33%) 8 (6) 7 (7) 8 (32) <0.0001
Cirrhosis 34 (26) 36 (35) 10 (40) 0.06

():% values; {}: interquartile range, reported with median value; *p < 0.05 vs. other genotypes.

Valenti et al.

Valenti et al. BMC Gastroenterology 2012 12:111   doi:10.1186/1471-230X-12-111

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