Table 5

Variables associated with and independent predictors of low adiponectin levels (<6 mg/ml) in 144 NAFLD patients and 257 healthy controls with very low probability of steatosis
Adiponectin Low (n = 217) High (n = 194) p OR * (95% c.i.) p *
NAFLD present 89 (46) 52 (24) 0.002 1.65 (1.02-2.70) 0.043
Age (years) 46±11 51±13 0.007 0.96 (0.94-0.98) <0.0001
Sex (F) 20 (9) 67 (34) <0.0001 0.21 (0.11-0.37) <0.0001
BMI (Kg/m2) 26.2±3.0 25.0±3.1 <0.0001 1.15 (1.07-1.25) 0.0002
HDL (mg/dl) 48±12 57±14 <0.0001 - -
Triglycerides (mg/dl) 119±68 92±47 <0.0001 - -
ALT (IU/ml) 42±38 29±25 <0.0001 - -
Insulin (IU/ml) 17±14 13±8 0.003 - -
FFAs (mmol/l) 0.21±0.09 0.19±0.08 0.05 - -
ADIPOQ
rs2241766TT and rs1501299T+ 83 (38) 100 (52) 0.008 0.61 (0.39-0.95) 0.030
rs2241766G + or rs1501299GG 134 (62) 94 (48) reference
PNPLA3 rs738409
CC (148 I/I) 97 (45) 112 (58) 0.01 1.67° (1.07-2.64) 0.024
CG (148 I/M) 94 (43) 71 (37)
GG (148 M/M) 26 (12) 11 (6)

():% values; * OR of low adiponectin at logistic regression analysis considering as independent variables the presence or not of NAFLD, age, gender, BMI, ADIPOQ and PNPLA3 genotype (additive model; OR per number of variant 148 M alleles).

Valenti et al.

Valenti et al. BMC Gastroenterology 2012 12:111   doi:10.1186/1471-230X-12-111

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