Table 3

Independent predictors of steatosis grade 2–3, NASH, and of fibrosis at logistic regression analysis in 115 consecutive biopsied patients with NAFLD with available DNA and serum samples at the time of liver biopsy
Variables Steatosis grade 2–3 vs. 1 NASH vs. simple steatosis Fibrosis vs. no fibrosis
OR (95% c.i.) p value OR (95% c.i.) p value OR (95% c.i.) p value
Age (years) 1.04 (0.99-1.09) 0.094 1.01 (0.96-1.06) 0.598 1.06 (1.01-1.10) 0.020
Sex (F) 1.31 (0.40-4.2) 0.656 0.88 (0.27-2.89) 0.834 0.55 (0.18-1.65) 0.282
BMI (Kg/m2) 1.22 (1.04-1.44) 0.014 1.32 (1.11-1.56) 0.002 1.13 (0.99-1.30) 0.079
ALT (IU/ml) 1.02 (1.01-1.03) 0.007 1.01 (1.00-1.02) 0.028 1.01 (1.00-1.02) 0.028
Glucose (mg/dl) 0.99 (0.98-1.01) 0.217 1.03 (1.00-1.05) 0.061 1.02 (0.99-1.04) 0.214
Insulin (IU/ml) 1.01 (0.97-1.06) 0.618 0.99 (0.94-1.04) 0.654 0.98 (0.94-1.03) 0.473
FFAs (mmol/l) 1.00 (0.98-1.01) 0.453 1.00 (0.99-1.01) 0.671 1.00 (0.99-1.01) 0.934
Adiponectin (μg/ml) 0.83 (0.72-0.96) 0.012 0.86 (0.75-0.98) 0.025 0.84 (0.74-0.95) 0.006

OR odds ratio, c.i. confidence interval, BMI body mass index, FFAs free fatty acids; the presence of NASH and fibrosis were defined according to the NASH clinical research network definition [31].

Valenti et al.

Valenti et al. BMC Gastroenterology 2012 12:111   doi:10.1186/1471-230X-12-111

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