Receiver operating characteristic (ROC) curves to classify the false positivity in METAVIR F1 to F3. Using alanine aminotransferase (ALT) levels (A) to discriminate the false positive in liver fibrosis evaluation using acoustic radiation force impulse elastography (n = 32) from the non false positive (n = 77) of the 109 patients with METAVIR F1, F2 and F3, the area under ROC curve (AUC) was 0.715 (standard error, SE, 0.053; 95% CI, 0.612-0.819; P < .001). The ALT level of 109.5 IU/L was the optimal cutoff value with a sensitivity of 56.3% and a specificity of 81.8%. Using the ActiTest A scores (B), the optimal cutoff was 0.35 (AUC, 0.736; SE, 0.051; 95% CI, 0.636-0.835; P < .001; sensitivity, 93.8%; specificity, 41.6%).
Chen et al. BMC Gastroenterology 2012 12:105 doi:10.1186/1471-230X-12-105