Table 2

Indirect Serum Markers of Liver Fibrosis.

Indices

Individual components

Sensitivity (%)

Specificity (%)


AST/ALT ratio

Aspartate aminotransferase,

Alanine aminotransferase

53

100


PGA

Protrombin index, GGT, apolipoprotein A1

91

81


APRI

AST/platelet count

89

75


FibroSpect II

HA, TIMP-1, α2-macroglobulin

83.5

66.7


FibroTest/FibroSure

γ2 macroglobulin, γ2 globulin, γ globulin, apolipoprotein A1, GGT, total bilirubin

75

85


FibroIndex

Platelet count, AST, GGT

78

74


FibroMeter

Platelet count, γ2 macroglobulin, AST, age, prothrombin index, HA, blood urea nitrogen

81

84


Forns

Age, platelet count, GGT, cholestered levels

94

51


Hepascore

Age, gender, bilirubin, GGT, HA, γ2-macroglobulin

63

89


FIB-4

Platelet count, ALT, AST, platelet count, age

70

74


SHASTA Index

HA, AST, albumin

100

52


Simple test

age, hyperglycemia, BMI, platelet count, albumin, AST/ALT

78

58


OELF/ELF

age, HA, N-terminal propeptide of type III collagen, TIMP-1

90

41


GGT: γ glutamyl transferase, HA: hyaluronic acid, TIMP-1: Tissue inhibitors of matrix metalloproteinase- 1, ALT: Alanine aminotransferase, AST: Aspartate aminotransferase

Baranova et al. BMC Gastroenterology 2011 11:91   doi:10.1186/1471-230X-11-91

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