A scheme depicting various means of liver fibrosis diagnostics. Liver biopsy is an invasive method that remains an imperfect golden standard. Proteomics based profiles are unlikely to be introduced to routine clinical care anytime soon, but are valuable from the research point of view. Imaging techniques, serum biomarkers and biomarker panels are advancing along the route to the clinic stage, but require extensive validation.
Baranova et al. BMC Gastroenterology 2011 11:91 doi:10.1186/1471-230X-11-91