Table 1

Tumorigenicity experiments of PLC/PRF/5 sphere-forming cells and parental cells in NOD/SCID mice

Cell type

Cell numbers injected

Tumor incidence

Latency(days)


Sphere-forming cells of the 3rd generation

2 × 102

0/3

-

5 × 102

1/3

35

1 × 103

3/3

23

2.5 × 103

3/3

23

5 × 103

3/3

20

1 × 104

3/3

16

5 × 104

2/2

9

1 × 105

2/2

7

2 × 105

2/2

7


Sphere-forming cells of the 6th generation

2 × 102

0/3

-

5 × 102

2/3

49

1 × 103

3/3

28


Sphere-forming cells of the 9th generation

2 × 102

0/3

-

5 × 102

1/3

40

1 × 103

3/3

30


PLC/PRF/5 parental cells

5 × 104

0/3

-

1 × 105

0/3

-

2 × 105

2/3

30

5 × 105

3/3

16

1 × 106

2/2

9


The number of tumors detected/number of injections.

Approximate number of days from tumor cell injection to appearance of a tumor.

Cao et al. BMC Gastroenterology 2011 11:71   doi:10.1186/1471-230X-11-71

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