Table 1

Hypercoagulability study in association with post-transplant thromboses

With thrombosis post-transplant (26 Cases)

Without thrombosis post-transplant (267 Cases)

Significance


RECIPIENT STUDY


Platelets (×109/L)

327.27 ± 88.0

264.89 ± 73.7

p < 0.001


PA (%)

101.96 ± 21.5

101.79 ± 16.4

p = 0.962


APTT (seconds)

31.24 ± 6.1

31.08 ± 4.4

p = 0.866


TT (seconds)

13.8 ± 2.2

14.22 ± 1.9

p = 0.301


Fibrinogen (mg/dL)

327.3 ± 88.7

264.89 ± 73.7

p < 0.001


AT (U/dL)

107.57 ± 18.3

99.57 ± 15.3

p = 0.013


PC chromogenic (U/dL)

61.34 ± 41.9

74.69 ± 39.8

p = 0.069


PC anticoagulant (U/dL)

94.68 ± 18.99

102.61 ± 27.5

p = 0.065


PS free antigen (U/dL)

84.0 ± 12.7

77.85 ± 14.2

p = 0.038


PS functional (U/dL)

95.4 ± 24.9

83.44 ± 22.3

p = 0.011


PS total (U/dL)

90.0 ± 9.0

93.9 ± 18.3

p = 0.716


Factor VIII (UI/dL

168.77 ± 60.8

153.95 ± 56.9

p = 0.209


ACA IgG (uFl)

5.84 ± 5.0

7.56 ± 16.49

p = 0.605


ACA IgM (uFl)

11.24 ± 18.64

9.3 ± 14.68

p = 0.539


Plasma homocysteine (μmoles/L)

13.79 ± 3.35

14.31 ± 8.7

p = 0.585


Factor V Leiden mutation (N°) (heterozygous) in recipient

1/26

6/264

p = 0.618


Prothrombin 20210A mutation (N°) (heterozygous) in recipient

0/26

13/264

p = 0.247


C677T MTHFR mutation (N°) (wild type/heterozygous/homozygous) in recipient

13/8/4

102/117/37

p = 0.402


APCR

2.86 ± 0.51

2.92 ± 0.51

p = 0.582


DONOR STUDY


Factor V Leiden mutation (N°) (heterozygous) in donor

0/26

4/196

p = 0.454


Prothrombin 20210A mutation (N°) (heterozygous) in donor

1/26

6/194

p = 0.865


C677T MTHFR mutation (N°) (wild type/heterozygous/homozygous) in donor

9/14/3

63/101/28

p = 0.915


PA (pro-thrombin activity); APTT (activated partial thromboplastin time); TT (thrombin clotting time); AT (anti-thrombin); PC (protein C); PS (protein S); ACA (anticardiolipin antibody); APCR (activated protein C resistance); (MTHFR) 5,10-methylenetetrahydrofolate reductase.

Ayala et al. BMC Gastroenterology 2011 11:130   doi:10.1186/1471-230X-11-130

Open Data