Table 3

Effect of moderate (3-5g) and low (1-3g) amounts of gluten on serum transglutaminase 2 (TG2) antibodies and small bowel mucosal TG2-targeted autoantibody deposits in treated celiac disease patients.

No

Mean daily gluten intake

Duration of gluten

Serum TG2 antibodies*

Mucosal TG2 antibody deposits†

I

II

I

II


Moderate amounts of gluten daily

1

5.0

29

10

319

0

+++

2

4.9

84

9

13

0

0

3

4.9

38

5

10

0

+

4

4.7

45

44

218

+

+++

5

4.1

61

6

5

0

0

6

4.0

91

21

263

+

+++

7

3.6

91

6

47

0

++

8

3.6

84

8

10

++

+

9

3.4

88

13

16

0

0

10

3.3

86

18

229

+

+++

Low amounts of gluten daily

11

2.8

89

6

7

0

++

12

2.7

84

7

111

0

++

13

2.6

81

7

5

0

0

14

2.4

85

12

88

0

++

15

2.2

103

9

9

0

0

16

2.1

93

16

94

++

++

17

2.1

85

9

8

0

0

18

2.1

84

24

21

+

+

19

2.1

83

8

8

0

0

20

1.4

77

10

13

0

+

21

1.3

78

14

101

0

++

Altogether positive outcome‡, n (%)

9 (43%)

11 (52%)


Clinically significant changes between baseline (I) and 12 weeks' follow-up examination (II) are marked in bold letters. Complete challenge lasted 12 weeks (84 ± 14 days).

* Values of ≥20 IU considered positive

† Graded as negative (0), weak (+), moderate (++) and strong positive (+++)

‡ Positive outcome reported when serum antibody levels or intensity of mucosal autoantibody deposits increased.

Lähdeaho et al. BMC Gastroenterology 2011 11:129   doi:10.1186/1471-230X-11-129

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