Table 2

Metabolic profile of healthy participants and HIV-infected patients segregated according to HCV co-infection and HIV-1 viral load

HIV-infected patients


Control group

Non-HCV co-infected group

HCV co-infected group



(n = 102)

VL < 40 copies/mL

VL > 40 copies/mL

VL < 40 copies/mL

VL > 40 copies/mL

(n = 47)

(n = 29)

(n = 67)

(n = 48)


FASN, μg/L

3.36 (0.92)

5.83 (1.34) a

5.08 (1.74) *

12.69 (2.01) c

14.41 (2.91) c

NEFA, mmol/L

0.65 (0.04)

0.62 (0.06)

0.64 (0.06)

0.63 (0.04)

0.61 (0.05)

Glucose, mmol/L

4.96 (0.16)

5.61 (0.20) c

5.2 (0.14) b

5.42 (0.12) c

5.16 (0.10) b

Insulin, pmol/L

64.6 (6.59)

69.22 (9.68)

47.95 (6.11) a,*

84.40 (10.79) a

76.31 (11.82)

HOMA-IR

1.15 (0.20)

1.33 (0.18)

0.92 (0.14) a,*

1.64 (0.22) a

1.48 (0.25)

Cholesterol, mmol/L

5.27 (0.12)

5.52 (0.19)

5.14 (0.23)

4.74 (0.15) c

4.41 (0.16) c

HDL-cholesterol, mmol/L

1.36 (0.03)

1.24 (0.09) a

1.15 (0.08) b

1.21 (0.05) b

1.07 (0.05) c, *

LDL-cholesterol, mmol/L

3.19 (0.79)

3.28 (0.17)

2.96 (0.17)

2.71 (0.13) c

2.38 (0.13) c

Triglyceride, mmol/L

1.27 (0.9)

3.00 (0.47) c

3.11 (1.01)

2.04 (0.18) c

3.24 (1.09) c

Apolipoprotein AI, g/L

1.69 (0.05)

1.44 (0.05) c

1.26 (0.04) c, **

1.40 (0.03) c

1.33 (0.04) c

Alanine aminotransferase, μKat/L

0.46 (0.02)

0.45 (0.03)

0.51 (0.04)

0.98 (0.11) c

0.97 (0.11) c

Aspartate aminotransferase, μKat/L

0.41 (0.02)

0.41 (0.03)

0.47 (0.08)

0.88 (0.09) c

0.88 (0.99) c


Values are the mean and the standard error of the mean (S.E.M.).

VL indicates HIV-1 viral load; HOMA-IR is homeostasis model assessment-estimated insulin resistance; NEFA is non-esterificated fatty acids.

a P < 0.05, b P < 0.01 and c P < 0.001 with respect to control group; * P < 0.05 and ** P = 0.006 with respect to patients with VL < 40 copies/mL in the corresponding group

Aragonès et al. BMC Gastroenterology 2010 10:92   doi:10.1186/1471-230X-10-92

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