Table 4

Effects of melatonin and omeprazole on patients with GERD group IV (n = 9)

Pretreatment with melatonin and omeprazole

4 weeks Post treatment with melatonin and omeprazole

Post 8 weeks treatment with melatonin and omeprazole


A) Symptoms:

1-Heart burn:

Yes

8

1(87.5%)

0 (100%)

Duration(months)

1.4 ± 0.4


2-Epigastric pain:

Yes

6

1(83.3%)

0 (100%)

ration(months)

1.3 ± 0.4


B) LES Study:

1-LES pressure(mmHg)

10.3 ± 1.68

14.5 ± 1.26a

20.5 ± 1.22ab


2-Residual pressure (mmHg)

0.012 ± 0.44

0.21 ± 0.016

0.33 ± 0.016a


3-Relaxation duration (seconds)

6.8 ± 0.16

5.8 ± 0.13a

5.2 ± 0.12a


4-Relaxation %

85 ± 1.58

90 ± 1.23a

100 ± 0.00ab


C) PH (at 5 cm above the LES):

1.98 ± 0.37

6.1 ± 0.55a

7.5 ± 0.31ab


D) BAO (mmol/h)

24.9 ± 0.7

15.8 ± 0.9a

10.2 ± 0.9ab


E) Serum Gastrin (pg/ml)

21.9 ± 4.7

33.6 ± 2.7a

36.8 ± 2.1ab


D) Melatonin level at day time (pg/ml):

18.3 ± 3.8

28.83 ± 1.82a

34.5 ± 2.35ab


a: p < 0.05 relative to pretreatment with melatonin

b: p < 0.05 relative to 4 weeks Post treatment with melatonin

Kandil et al. BMC Gastroenterology 2010 10:7   doi:10.1186/1471-230X-10-7

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