Table 2

Effects of melatonin on patients with GERD group II (n = 9)

Pretreatment with melatonin

4 weeks Post treatment with melatonin

8 weeks Post treatment with melatonin


Symptoms:

1-Heart burn:

Yes

7

3 (57.1%)

0 (100%)

Duration(months)

1.3 ± 0.4


2-Epigastric pain:

Yes

6

3 (50%)

1 (83%)

Duration(months)

1.4 ± 0.5


B)LES Study:

1-LES pressure(mmHg)

10 ± 1.58

14.5 ± 1.58a

20.2 ± 1.56 ab


2-Residual pressure (mmHg)

0.012 ± 0.52

0.2 ± 0.016

0.32 ± 0.013a


3-Relaxation duration (seconds)

6.8 ± 0.12

5.9 ± 0.16 a

5.3 ± 0.12 a


4-Relaxation %

86 ± 0.87

90 ± 0.86 a

100 ± 0.00 ab


C) PH (at 5 cm above the LES):

2.3 ± 0.36

5.2 ± 0.5 a

6.7 ± 0.65 ab


D) BAO (mmol/h)

24.7 ± 0.5

20.1 ± 0.4 a

16.6 ± 0.6 ab


E) Serum Gastrin(pg/ml)

22.1 ± 3.2

27.2 ± 2.3 a

32.3 ± 2.1 ab


D) Melatonin level at day time (pg/ml):

18.2 ± 5.54

28.26 ± 2.26 a

34.5 ± 2.35 ab


a: p < 0.05 relative to pretreatment with melatonin

b: p < 0.05 relative to 4 weeks post treatment with melatonin

Kandil et al. BMC Gastroenterology 2010 10:7   doi:10.1186/1471-230X-10-7

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