Table 1

Comparison of control subjects and patients pretreated with melatonin, omeprazole and both (n = 9)

control

Pretreatment with melatonin

Pretreatment with omeprazole

Pretreatment with melatonin and omeprazole


Symptoms:

1-Heart burn:

Yes

0

7

7

8

Duration(months)

1.3 ± 0.4

1.2 ± 0.3

1.4 ± 0.4


2-Epigastric pain:

Yes

0

6

6

6

Duration(months)

1.4 ± 0.5

1.3 ± 0.4

1.3 ± 0.4


A)LES Study:

1-LES pressure(mmHg)

22.8 ± 1.3

10 ± 1.58a

10.5 ± 2.86a

10.3 ± 1.68a


2-Residual pressure (mmHg)

0.4 ± 0.01

0.012 ± 0.52a

0.1 ± 0.064a

0.012 ± 0.44a


3-Relaxation duration (seconds)

5.0 ± 0.1

6.8 ± 0.12a

6.5 ± 2.74a

6.8 ± 0.16a


4-Relaxation %

100 ± 0.00

86 ± 0.87a

87.2 ± 0.17a

85 ± 1.58a


C) PH (at 5 cm above the LES):

7.8 ± 0.4

2.3 ± 0.36a

2.1 ± 0.38a

1.98 ± 0.37a


D) BAO (mmol/h)

2.6 ± 0.6

24.7 ± 0.5a

25.1 ± 0.6a

24.9 ± 0.7a


E) Serum Gastrin(pg/ml)

41.8 ± 7.1

22.1 ± 4.2a

21.5 ± 4.6a

21.9 ± 4.7a


D) Melatonin level at day time (pg/ml):

36.1 ± 2.3

18.2 ± 5.54a

18.5 ± 3.75a

18.3 ± 3.8a


a: p < 0.05 relative to control

Kandil et al. BMC Gastroenterology 2010 10:7   doi:10.1186/1471-230X-10-7

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