Table 4 |
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|
Results |
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|
Buprenorphine (total 28) |
Dihydrocodeine (total 32) |
Odds Ratio (95% CI) |
Relative Risk (95% CI) |
P value |
|
|
|
|||||
|
By end of detox |
|||||
|
Final urine sample |
9 (32%) |
4 (13%) |
3.32 (0.77–15.22) |
1.71 (1.04–2.83) |
0.065 |
|
Non-ITT Clean urine |
6/9 (67%) |
1/4 (25%) |
6.00 (0.28–246) |
1.71 (0.73–4.03) |
0.164 |
|
ITT-1* clean urine |
6/28 (21%) |
1/32 (3%) |
8.45 (0.89–200) |
2.06 (1.33–3.21) |
0.028 |
|
ITT-2* clean urine |
6+3/28 |
1+8/32 |
1.21 (0.35–4.21) |
1.11 (0.63–1.95) |
0.735 |
|
Leaving early |
19 (68%) |
28 (88%) |
0.30 (0.07–1.30) |
0.58 (0.35–0.96) |
0.065 |
|
Overdose |
0 |
0 |
Not applicable |
||
|
Inappropriate use of allocated drug |
0 |
0 |
Not applicable |
||
|
A&E attendance |
0 |
0 |
Not applicable |
||
|
Admitted |
0 |
0 |
Not applicable |
||
|
Overdose |
0 |
0 |
Not applicable |
||
|
GP visits – mean |
2.2 (1.05) |
2.8 (1.33) |
0.06 |
||
|
Drug worker visits – mean |
0.17 (0.47) |
1.31 (0.59) |
0.343 |
||
|
At 3 months post detoxification |
|||||
|
Abstinent |
10/27 (37%) |
4/24 (17%) |
2.94 (0.67–13.78) |
1.55 (0.96–2.52) |
0.104 |
|
Dead |
0/27 |
0/28 |
Not applicable |
||
|
On Med 3 sick note |
10/16 (63%) |
6/14 (43%) |
2.22 (0.41–12.65) |
1.46 (0.71–2.98) |
0.282 |
|
A&E attendance |
2/27 (7%) |
2/28 (7%) |
1.04 (0.09–11.46) |
1.06 (0.38–2.94) |
0.970 |
|
Hospital attendance |
1/27 (4%) |
2/28 (7%) |
0.5 (0.02–7.75) |
0.67 (0.13–3.38) |
0.574 |
|
GP visits – mean |
5.04 (4.85) |
4.61 (4.10) |
0.724 |
||
|
Drug worker visits – mean |
1.22 (1.67) |
1.14 (1.53) |
0.855 |
||
|
At 6 months post detoxification |
|||||
|
Abstinent |
7/22 (32%) |
3/19 (16%) |
2.49 (0.45–15.15) |
1.45 (0.84–2.49) |
0.233 |
|
Dead |
0/23 |
0/20 |
Not applicable |
||
|
On Med 3 sick note |
3/11 (27%) |
2/11 (18%) |
1.69 (0.16–20.05) |
1.27 (0.53–3.06) |
0.611 |
|
A&E attendance |
0/22 |
0/20 |
Not applicable |
||
|
Hospital attendance |
0/22 |
2/20 (10%) |
0.16 (0.01–3.64) |
0.129 |
|
|
GP visits – mean |
7.54 (6.71) |
6.48 (6.07) |
0.582 |
||
|
Drug worker visits – mean |
1.74 (2.40) |
2.65 (2.89) |
0.265 |
||
|
|
|||||
|
• Assumption 1 = everybody not returning for final urine test had not clean urine • Assumption 2 = everybody not returning for final urine test had same proportion of not clean urine as those who did |
|||||
|
Wright et al. BMC Family Practice 2007 8:3 doi:10.1186/1471-2296-8-3 |
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