Table 5

Diagnostic accuracy of age-specific PSA levels

Age

PSA cutoff (ng/mL)

Sensitivity (%)

Specificity (%)

LR + (95% CI)

LR – (95% CI)

40 – 49

2.5

85

42

1.47 (1.11, 1.93)

0.35 (0.13, 0.96)

50 – 59

3.5

86

38

1.38 (1.25, 1.54)

0.36 (0.24, 0.56)

60 – 69

4.5

78

36

1.22 (1.14, 1.32)

0.60 (0.49, 0.74)

≥ 70

6.5

70

49

1.38 (1.24, 1.53)

0.61 (0.52, 0.73)

Abbreviations: PSA = prostate-specific antigen. LR+ = likelihood ratio for a positive test. LR- = likelihood ratio for a negative test. CI = confidence interval.

Hoffman et al. BMC Family Practice 2002 3:19   doi:10.1186/1471-2296-3-19