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Open Access Study protocol

Individual patient data meta-analysis of diagnostic and prognostic studies in obstetrics, gynaecology and reproductive medicine

Kimiko A Broeze*, Brent C Opmeer, Lucas M Bachmann, Frank J Broekmans, Patrick MM Bossuyt, Sjors FPJ Coppus, Neil P Johnson, Khalid S Khan, Gerben ter Riet, Fulco van der Veen, Madelon van Wely and Ben WJ Mol

BMC Medical Research Methodology 2009, 9:22  doi:10.1186/1471-2288-9-22

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Previous IPD diagnostic and prognostic reviews

Bob Phillips   (2010-03-17 16:33)  University of York email

Diagnostic tests and prognostic variables have been subject to previous IPD meta-analysis. Some of these include:

Royston, P., M.K. Parmar, and R. Sylvester, Construction and validation of a prognostic model across several studies, with an application in superficial bladder cancer. Stat Med, 2004. 23(6): p. 907-26.

Fibrinogen Studies Collaboration, Plasma Fibrinogen Level and the Risk of Major Cardiovascular Diseases and Nonvascular Mortality: An Individual Participant Meta-analysis. JAMA, 2005. 294(14): p. 1799-1809.

Trivella, M., et al., Microvessel density as a prognostic factor in non-small-cell lung carcinoma: a meta-analysis of individual patient data. Lancet Oncol, 2007. 8(6): p. 488-99.

Mant, J., et al., Systematic review and individual patient data meta-analysis of diagnosis of heart failure, with modelling of implications of different diagnostic strategies in primary care. Health Technol Assess, 2009. 13(32): p. 1-207, iii.

Further development of the methods, as well as dissemination of the results of the planned reviews, remains essential however.

Competing interests

None

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