Table 1

Validation of statistical procedures. Validation of different statistical procedures using a simulated data-set. Results of Meta-DiSc (version 1.4) are compared with those obtained with metan (version 1.86) and metareg (version 1.06) STATA commands. Prior to the analyses, all four cells of all studies were added with 1/2 to avoid division by zero when computing some indices or standard errors. Meta-DiSc and STATA data-set are provided as additional files [see 1] and [see 2].

Results


Procedure

Meta-DiSc (version 1.4)

STATA (ver 8.2)


Random Effect Model

Pooled +ve LR

2.447

2.447

(95%(CI)

(2.085 – 2.871)

(2.085 – 2.871)

Tau-square

0.0932

0.0932

Cochrane-Q

139.71

139.71

Pooled -ve LR

0.157

0.157

(95%(CI)

(0.095 – 0.257)

(0.095 – 0.257)

Tau-square

0.4631

0.46357

Cochrane-Q

33.00

33.07

Fixed Effect Model

Pooled +ve LR

2.330

2.330

(95%(CI)

(2.208 – 2.459)

(2.208 – 2.459)

Cochrane-Q

139.71

139.71

Pooled -ve LR

0.105

0.104

(95%(CI)

(0.073 – 0.149)

(0.073 – 0.148)

Cochrane-Q

33.00

33.07

Meta-Regression1

Tau-Square

0.1141

0.1141

Constant coefficient (SE)

2.520 (0.8370)

2.5197 (0.83699)

S coefficient (SE)

0.330 (0.1912)

0.3304 (0.19123)

Covariable coefficient (SE)

-0.036 (0.0904)

-0.0355 (0.09041)


(1) Meta-regression was weighted by the inverse of the variance of dOR and between study variance was estimated by REML.

Zamora et al. BMC Medical Research Methodology 2006 6:31   doi:10.1186/1471-2288-6-31

Open Data