Table 5

Marginal model and random-effects models analysing the influence of time and age


Marginal model GEE
Random model likelihood integration

Estimate
SE
p value
Estimate
SE
p value



Intercept
-1.83
0.12
< 0.0001
-3.61
0.25
< 0.0001
Time (years)
0.12
0.03
< 0.0001
0.17
0.06
0.002
Age at baseline*
0.09
0.02
< 0.0001
0.16
0.03
< 0.0001
Age* × time
0.01
0.004
0.003
0.04
0.009
< 0.0001
Baseline disability
1.54
0.10
< 0.0001
3.18
0.22
< 0.0001
Death during the study
0.68
0.12
< 0.0001
1.36
0.26
< 0.0001
Random intercept variance
-
-
-
7.25
0.68
< 0.0001
Random slope variance
-
-
-
0.18
0.04
< 0.0001

Carrière and Bouyer BMC Medical Research Methodology 2002 2:15   doi:10.1186/1471-2288-2-15