Table 2

Highly Sensitive Search Strategy for identifying off-label drug use reports in OvidSP EMBASE: sensitivity-maximizing version
Search query Cumulative number of relevant records retrieved Cumulative number of records retrieved Cumulative sensitivity/full set (%) Cumulative sensitivity/EMBASE set (%) Cumulative Precision (%)
1 off label*.af. 3150 3577 77.45 81.90 88.06
2 (off adj1 label).mp. 3152 3581 77.50 81.96 88.02
3 (drug adj2 label adj2 us*).af. 3153 3617 77.53 81.98 87.17
4 unlicense*.af. 3279 4320 80.62 85.26 75.90
5 unapprove*.af. 3445 4635 84.71 89.57 74.33
6 (label adj3 indication*).af. 3450 4667 84.83 89.70 73.92
7 off li?en?e*.af. 3509 4742 86.28 91.24 74.00
8 ((no* licen?ed for adj3 use*) not now licen?ed).af. 3560 4825 87.53 92.56 73.78
9 ((inappropriate us* and indication) not (antibiotic* or antimicrobial)).af. 3609 4964 88.74 93.84 72.70
10 ((appropriate* adj3 prescri*) and indication).af. 3648 5081 89.70 94.85 71.80
11 (outside adj3 licen?e*).af. 3665 5110 90.12 95.29 71.72
12 unlabel* us*.af. 3692 5140 90.78 96.00 71.83
13 labeled indication*.af. 3703 5169 91.05 96.28 71.64
14 (inappropriate indication*).af. 3719 5294 91.44 96.70 70.25
15 nonapprove*.af. 3737 5337 91.89 97.17 70.02
16 registered indication*.af. 3752 5367 92.25 97.56 69.91
17 offlabel*.af. 3757 5372 92.38 97.69 69.94
18 (out* adj4 licen?ed indication*).af. 3759 5376 92.43 97.74 69.92
19 (unlabel* adj3 indication*).af. 3767 5384 92.62 97.95 69.97
20 non fda approve*.af. 3780 5411 92.94 98.28 69.86
21 ((no* licen?ed for adj3 indication*) not now licen?ed).af. 3793 5425 93.26 98.62 69.92
22 (appropriate indication adj3 us*).af. 3796 5432 93.34 98.70 69.88
23 (be???d* adj2 licen?ed indication*).af. 3799 5436 93.41 98.78 69.89
24 (us* without adj2 indication*).af. 3804 5445 93.53 98.91 69.86
25 (prescri* outside adj4 guideline*).af. 3808 5450 93.63 99.01 69.87
26 (out of label).af. 3810 5466 93.68 99.06 69.70
27 (improper adj1 indication*).af. 3812 5472 93.73 99.12 69.66
28 (inappropriate adj5 indication adj2 us*).af. 3814 5475 93.78 99.17 69.66
29 no* appropriate indication*.af. 3815 5482 93.80 99.19 69.59
30 (non evidence base* us*).af. 3818 5487 93.88 99.27 69.58
31 without proper indication*.af. 3821 5498 93.95 99.35 69.50
32 (or/1-31) or (drug* without adj2 indication*).af. 3822 5501 93.98 99.38 69.48

Combinations of search queries with the best sensitivity are ranked in descending order of number of relevant records.

Mesgarpour et al.

Mesgarpour et al. BMC Medical Research Methodology 2012 12:190   doi:10.1186/1471-2288-12-190

Open Data