Table 5 |
|||||||
| Estimated parameters of the conditional LCAs in the OHTS and EGPS data | |||||||
| OHTS | |||||||
| Variables | Parameters for IOP change and the effects of covariates on class membership | Effects on POAG | |||||
| Class 1 | Class2 (Ref.) | Class 3 | Class 4 | Class 5 | Class 6 | ||
| Class Size IOP Change | 14.2% | 27.1% | 21.1% | 9.1% | 17.6% | 10.9% | |
| I | 17.58(0.20)# | 19.83(0.21)# | 22.30(0.21)# | 22.82(0.79)# | 24.74(0.22)# | 27.70(0.28)# | - |
| L | −0.57(0.08)# | −0.53(0.06)# | −0.47(0.09)# | −0.95(0.30)# | −0.20(0.09)* | 0.16(0.17) | - |
| Q | 0.06(0.01)# | 0.05(0.01)# | 0.05(0.01)# | 0.07(0.04) | 0.02(0.02) | −0.05(0.03) | - |
| V | 4.36(0.27)# | 4.30(0.32)# | 4.80(0.25)# | 16.07(1.46)# | 4.66(0.31)# | 12.15(1.15)# | - |
| Covariates | |||||||
| Intercept | −2.64(0.63)# | 2.08(0.47)# | −0.06(0.47) | 2.35(0.54)# | 1.04(0.61) | - | |
| TRT | 1.60(0.66)* | - | −3.25(0.35)# | −2.19(0.63)# | −5.98(0.56)# | −6.46(0.70)# | 0.16(0.29) |
| MALE | 0.25(0.23) | - | −0.99(0.24)# | 0.24(0.27) | −0.68(0.28)* | −0.22(0.30) | 0.23(0.19) |
| RACEB | −0.10(0.27) | - | −0.37(0.30) | 0.75(0.31)* | −0.91(0.34)* | 0.05(0.37) | −0.05(0.24) |
| AGE | 0.06(0.12) | - | −0.01(0.12) | 0.08(0.16) | −0.05(0.14) | 0.13(0.15) | 0.18(0.09) * |
| IOP0 | −0.79(0.18)# | - | 0.21(0.22) | 1.03(0.36)* | 0.89(0.18)# | 1.73(0.22)# | −0.10(0.11) |
| CCT | −0.35(0.12)* | - | 0.18(0.11) | −0.08(0.17) | 0.14(0.13) | 0.09(0.16) | −0.64(0.13)# |
| PSD | 0.13(0.11) | - | 0.04(0.11) | 0.08(0.13) | 0.17(0.13) | 0.12(0.15) | 0.23(0.10)* |
| VCD | 0.06(0.11) | - | −0.08(0.12) | −0.15(0.17) | −0.10(0.13) | −0.09(0.15) | 0.60(0.10)# |
| BB | −0.60(0.48) | - | −0.37(0.61) | - ** | −0.30(0.62) | −1.21(0.77) | 0.19(0.57) |
| CHB | −0.19(0.37) | - | −0.32(0.42) | 0.47(0.45) | −0.42(0.44) | −0.50(0.49) | 0.09(0.31) |
| DM | −0.23(0.35) | - | 0.22(0.32) | −0.71(0.45) | 0.23(0.36) | 0.64(0.40) | −1.67(0.53)* |
| HEART | 0.70(0.44) | - | 0.10(0.49) | 0.43(0.56) | −0.09(0.56) | −0.48(0.73) | 0.71(0.29)* |
| HBP | 0.47(0.24)* | - | 0.40(0.27) | 0.06(0.34) | 0.41(0.30) | 0.66(0.33)* | 0.08(0.22) |
| EGPS | |||||||
| Variables | Parameters for IOP change and the effects of covariates on class membership | Effects on POAG | |||||
| Class1 (Ref.) | Class 2 | Class 3 | Class 4 | Class 5 | |||
| Class Size IOP Change | 26.3% | 20.1% | 29.3% | 12.9% | 11.4% | ||
| I | 18.66(0.25) # | 18.24(0.18)# | 21.24(0.20)# | 21.85(0.47)# | 24.33(0.34)# | - | |
| L | −0.34(0.14)* | −1.29(0.18)# | −0.25(0.11)* | −1.76(0.28)# | 0.06(0.26) | - | |
| Q | 0.05(0.03) | 0.11(0.04)* | 0.02(0.03) | 0.02(0.07) | −0.08(0.07) | - | |
| V | 3.79(0.23)# | 3.75(0.25)# | 4.59(0.24)# | 7.12(0.85)# | 12.17(1.32)# | - | |
| Covariates | |||||||
| Intercept | - | −0.84(0.33)* | 0.30(0.28) | −0.85(0.58) | −0.71(0.34)* | - | |
| TRT | - | 0.36(0.27) | −0.65(0.23)* | −0.58(0.37) | −1.79(0.37)# | −0.01(0.21) | |
| MALE | - | −0.35(0.29) | 0.14(0.23) | 0.18(0.40) | 0.38(0.33) | −0.24(0.22) | |
| Black | - | - | - | - | - | - | |
| AGE | - | −0.09(0.16) | 0.01(0.13) | 0.40(0.23) | 0.45(0.20)* | 0.16(0.10) | |
| IOP0 | - | −0.61(0.24)* | 0.82(0.17)# | 1.24(0.24)# | 1.79(0.23)# | 0.11(0.13) | |
| CCT | - | −0.33(0.13)* | −0.14(0.12) | −0.43(0.15)* | 0.09(0.15) | −0.36(0.12)* | |
| PSD | - | 0.27(0.16) | −0.23(0.14) | −0.18(0.24) | −0.41(0.23) | 0.18(0.09)* | |
| VCD | - | −0.13(0.17) | −0.03(0.13) | 0.72(0.26)* | 0.17(0.16) | 0.46(0.12)# | |
| BB | - | −0.17(0.50) | −0.82(0.52) | - ** | −0.58(0.69) | −0.07(0.41) | |
| CHB | - | −0.10(0.56) | −0.97(0.52) | 0.89(1.03) | −1.22(0.79) | −0.28(0.47) | |
| DM | - | −0.46(0.52) | 0.12(0.45) | −1.32(1.27) | 0.82(0.81) | −0.18(0.54) | |
| HEART | - | 0.78(0.41) | 0.11(0.44) | −0.83(0.77) | −0.79(0.61) | 0.74(0.32)* | |
| HBP | - | 0.02(0.36) | 0.53(0.30) | −1.27(0.90) | 0.11(0.54) | 0.24(0.26) | |
*: p < 0.05; #: p < 0.001; **: Not estimable due to zero count of beta blocker use in the given class.
Gao et al. BMC Medical Research Methodology 2012 12:151 doi:10.1186/1471-2288-12-151
