Table 5

Estimated parameters of the conditional LCAs in the OHTS and EGPS data
OHTS
Variables Parameters for IOP change and the effects of covariates on class membership Effects on POAG
Class 1 Class2 (Ref.) Class 3 Class 4 Class 5 Class 6
Class Size IOP Change 14.2% 27.1% 21.1% 9.1% 17.6% 10.9%
 I 17.58(0.20)# 19.83(0.21)# 22.30(0.21)# 22.82(0.79)# 24.74(0.22)# 27.70(0.28)# -
 L −0.57(0.08)# −0.53(0.06)# −0.47(0.09)# −0.95(0.30)# −0.20(0.09)* 0.16(0.17) -
 Q 0.06(0.01)# 0.05(0.01)# 0.05(0.01)# 0.07(0.04) 0.02(0.02) −0.05(0.03) -
 V 4.36(0.27)# 4.30(0.32)# 4.80(0.25)# 16.07(1.46)# 4.66(0.31)# 12.15(1.15)# -
Covariates
 Intercept −2.64(0.63)# 2.08(0.47)# −0.06(0.47) 2.35(0.54)# 1.04(0.61) -
 TRT 1.60(0.66)* - −3.25(0.35)# −2.19(0.63)# −5.98(0.56)# −6.46(0.70)# 0.16(0.29)
 MALE 0.25(0.23) - −0.99(0.24)# 0.24(0.27) −0.68(0.28)* −0.22(0.30) 0.23(0.19)
 RACEB −0.10(0.27) - −0.37(0.30) 0.75(0.31)* −0.91(0.34)* 0.05(0.37) −0.05(0.24)
 AGE 0.06(0.12) - −0.01(0.12) 0.08(0.16) −0.05(0.14) 0.13(0.15) 0.18(0.09) *
 IOP0 −0.79(0.18)# - 0.21(0.22) 1.03(0.36)* 0.89(0.18)# 1.73(0.22)# −0.10(0.11)
 CCT −0.35(0.12)* - 0.18(0.11) −0.08(0.17) 0.14(0.13) 0.09(0.16) −0.64(0.13)#
 PSD 0.13(0.11) - 0.04(0.11) 0.08(0.13) 0.17(0.13) 0.12(0.15) 0.23(0.10)*
 VCD 0.06(0.11) - −0.08(0.12) −0.15(0.17) −0.10(0.13) −0.09(0.15) 0.60(0.10)#
 BB −0.60(0.48) - −0.37(0.61) - ** −0.30(0.62) −1.21(0.77) 0.19(0.57)
 CHB −0.19(0.37) - −0.32(0.42) 0.47(0.45) −0.42(0.44) −0.50(0.49) 0.09(0.31)
 DM −0.23(0.35) - 0.22(0.32) −0.71(0.45) 0.23(0.36) 0.64(0.40) −1.67(0.53)*
 HEART 0.70(0.44) - 0.10(0.49) 0.43(0.56) −0.09(0.56) −0.48(0.73) 0.71(0.29)*
 HBP 0.47(0.24)* - 0.40(0.27) 0.06(0.34) 0.41(0.30) 0.66(0.33)* 0.08(0.22)
EGPS
Variables Parameters for IOP change and the effects of covariates on class membership Effects on POAG
Class1 (Ref.) Class 2 Class 3 Class 4 Class 5
Class Size IOP Change 26.3% 20.1% 29.3% 12.9% 11.4%
 I 18.66(0.25) # 18.24(0.18)# 21.24(0.20)# 21.85(0.47)# 24.33(0.34)# -
 L −0.34(0.14)* −1.29(0.18)# −0.25(0.11)* −1.76(0.28)# 0.06(0.26) -
 Q 0.05(0.03) 0.11(0.04)* 0.02(0.03) 0.02(0.07) −0.08(0.07) -
 V 3.79(0.23)# 3.75(0.25)# 4.59(0.24)# 7.12(0.85)# 12.17(1.32)# -
Covariates
 Intercept - −0.84(0.33)* 0.30(0.28) −0.85(0.58) −0.71(0.34)* -
 TRT - 0.36(0.27) −0.65(0.23)* −0.58(0.37) −1.79(0.37)# −0.01(0.21)
 MALE - −0.35(0.29) 0.14(0.23) 0.18(0.40) 0.38(0.33) −0.24(0.22)
 Black - - - - - -
 AGE - −0.09(0.16) 0.01(0.13) 0.40(0.23) 0.45(0.20)* 0.16(0.10)
 IOP0 - −0.61(0.24)* 0.82(0.17)# 1.24(0.24)# 1.79(0.23)# 0.11(0.13)
 CCT - −0.33(0.13)* −0.14(0.12) −0.43(0.15)* 0.09(0.15) −0.36(0.12)*
 PSD - 0.27(0.16) −0.23(0.14) −0.18(0.24) −0.41(0.23) 0.18(0.09)*
 VCD - −0.13(0.17) −0.03(0.13) 0.72(0.26)* 0.17(0.16) 0.46(0.12)#
 BB - −0.17(0.50) −0.82(0.52) - ** −0.58(0.69) −0.07(0.41)
 CHB - −0.10(0.56) −0.97(0.52) 0.89(1.03) −1.22(0.79) −0.28(0.47)
 DM - −0.46(0.52) 0.12(0.45) −1.32(1.27) 0.82(0.81) −0.18(0.54)
 HEART - 0.78(0.41) 0.11(0.44) −0.83(0.77) −0.79(0.61) 0.74(0.32)*
 HBP - 0.02(0.36) 0.53(0.30) −1.27(0.90) 0.11(0.54) 0.24(0.26)

*: p < 0.05; #: p < 0.001; **: Not estimable due to zero count of beta blocker use in the given class.

Gao et al.

Gao et al. BMC Medical Research Methodology 2012 12:151   doi:10.1186/1471-2288-12-151

Open Data