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Open Access Highly Accessed Research article

Assessing methods for dealing with treatment switching in randomised controlled trials: a simulation study

James P Morden*, Paul C Lambert, Nicholas Latimer, Keith R Abrams and Allan J Wailoo

BMC Medical Research Methodology 2011, 11:4  doi:10.1186/1471-2288-11-4

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Law & Kaldor method

Ian R White   (2011-03-25 14:41)  MRC Biostatistics Unit email

This article quotes me as saying (in reference 13) that the Law & Kaldor method is likely to be biased towards the null. But in fact reference 13 illustrates a far worse situation: data were simulated with no treatment effect, yet the Law & Kaldor method estimated an "adjusted" hazard ratio of 1.48 (95% CI 1.44 to 1.52). By contrast, methods based on a structural model have the highly desirable property of being unbiased under the null.

Competing interests

None

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