Table 3

Association of Fetal Hypoxia at Birth1 and Diagnosis of Autism Spectrum Disorders2: Results of Logistic Regression Fitted with EM Algorithm for Handling Unknown Exposures That are Modeled From Maternal and Birth Characteristics Under MAR Assumption (r = 1) Stratified on Child's Gender

All gestational ages at birth


Unadjusted

Adjusted


Child's Gender

Both

Male

Female

Both3

Male4

Female4


Odds ratio estimate

1.15

1.14

0.93

1.11

1.13

0.94


95% confidence interval

0.98, 1.33

0.97, 1.34

0.62, 1.40

0.95, 1.29

0.96, 1.33

0.62, 1.41


P-value

0.08

0.11

0.74

0.19

0.14

0.76


Full-term births only


Unadjusted

Adjusted


Child's Gender

Both

Male

Female

Both3

Male4

Female4


Odds ratio estimate

1.11

1.10

0.92

1.07

1.09

0.93


95% confidence interval

0.94, 1.31

0.93, 1.31

0.60, 1.42

0.91, 1.34

0.91, 1.29

0.60, 1.56


P-value

0.21

0.23

0.71

0.42

0.35

0.74


1: at least one of the three tests for fetal hypoxia is positive, i.e. fetal scalp pH < 7.25, or umbilical artery pH < 7.20, or venous pH < 7.28

2: singletons born in Alberta 1998-2004 and followed up till March 31, 2008

3: adjusted for gender, birth year and socio-economic status

4: adjusted for birth year and socio-economic status

Burstyn et al. BMC Medical Research Methodology 2011 11:2   doi:10.1186/1471-2288-11-2

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