Open Access Research article

Autism spectrum disorders and fetal hypoxia in a population-based cohort: Accounting for missing exposures via Estimation-Maximization algorithm

Igor Burstyn12*, Xiaoming Wang34, Yutaka Yasui3, Fortune Sithole1 and Lonnie Zwaigenbaum5

Author Affiliations

1 Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

2 Department of Environmental and Occupational Health, School of Public Health, Drexel University, Philadelphia, Pennsylvania, USA

3 Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, Canada

4 School of Statistics and Management, Shanghai University of Finance and Economics, Shanghai, China

5 Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

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BMC Medical Research Methodology 2011, 11:2  doi:10.1186/1471-2288-11-2

Published: 5 January 2011

Additional files

Additional file 1:

EM Algorithm with either MAR or NMAR assumptions. Mathematical details of EM algorithm implemented in this article.

Format: DOC Size: 174KB Download file

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Additional file 2:

Implementation of EM Algorithm for missing values in SAS software. SAS code that was used to implement EM algorithm presented in this article with annotation that allow adapting it to similar applications.

Format: DOCX Size: 18KB Download file

Open Data