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Open Access Highly Accessed Research article

Can we rely on the best trial? A comparison of individual trials and systematic reviews

Paul P Glasziou*, Sasha Shepperd and Jon Brassey

BMC Medical Research Methodology 2010, 10:23  doi:10.1186/1471-2288-10-23

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Vin��cius Ynoe Moraes   (2010-03-22 22:57)  FEDERAL UNIVERSITY OF SAO PAULO email

This is a very interesting manuscript, very creative and relevant. It is a fact that regarding to treatment issues we do not have the access to an up-to-date systematic review, in some cases. Therefore, this paper strenghtes a personal belief that we can rely on the largest trial, specially if it respects the treatment effect issues and (what i believe to be THE ISSUE) HAS AN EXPLICT AND CLEAR prevous power anaysis. Thanks for this pleasant reading and congratulations.

Competing interests

I declare no competing interests


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