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This article is part of the supplement: Abstracts from the 2012 PLA Emergency Medicine Annual Congress

Open Access Meeting abstract

Clinical usefulness of T-SPOT.TB in the diagnosis tuberculosis in emergency patients

HU Xiao-min, LIU Jian, LEI Long and YIN Wen*

Author Affiliations

Department of Emergency Xijing Hospital, the Fourth Military Medical University, Changle Xilu Road No.127, Xi'an 710032, China

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BMC Emergency Medicine 2012, 12(Suppl 1):A7  doi:10.1186/1471-227X-12-S1-A7

The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-227X/12/S1/A7


Published:18 December 2012

© 2012 Xiao-min et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Objective

To evaluate the diagnostic value of an interferon-gamma release assay T-SPOT.TB in tuberculosis of emergency patients.

Methods

The emergency patients with suspected tuberculosis received T-SPOT.TB assay in the peripheral blood mononuclear cells(PBMCs).

Results

T-SPOT.TB assay, PPD, anti-TB antibody test, M tuberculosis polymerase chain reaction, acid-fast bacilli stain and cultures for M tuberculosis were positive in 96.8%(31/32), 43.7%(14/32), 21.8%(7/32), 15.6%(5/32), 13.0%(3/23) and 4.3%(1/23), respectively, of patients with active tuberculosis. The sensitivity and specificity of the T-SPOT.TB were 96.8% and 98.3%.

Conclusions

T-SPOT.TB assay is a rapid and high-sensitive tests for diagnosing tuberculosis in emergency patients.