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This article is part of the supplement: Abstracts from the 2012 PLA Emergency Medicine Annual Congress

Open Access Meeting abstract

Effect of the Xuebijing oral solution on survival of rabbits with acute paraquat poisoning

Song Zu-jun1, Chen Gao-fei2*, Ao Guo-kun3 and Cao Jian-xiao3

Author Affiliations

1 Department of Emergency The 309th Hospital of Chinese People’s Liberation Army,17 Heishanhu Road, Haidian District,Beijing 100091, People’s Republic of China

2 The Fourth Military Medical University; No.127 Changle Xilu Road Xi'an 710032, People’s Republic of China

3 Department of Rodiology The 309th Hospital of Chinese People’s Liberation Army, 17 Heishanhu Road, Haidian District, Beijing 100091, People’s Republic of China

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BMC Emergency Medicine 2012, 12(Suppl 1):A6  doi:10.1186/1471-227X-12-S1-A6


The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-227X/12/S1/A6


Published:18 December 2012

© 2012 Zu-jun et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Objective

To study the effect of the Xuebijing oral solution on survival of rabbits with acute paraquat poisoning.

Methods

30 New Zealand white rabbits were randomly divided into saline control group(group A) and two treatment groups of 3ml/kg(group B) and 10ml/kg(group C) of Xuebijing oral solution.All the rabbits were treated with PQ at 35mg/kg through intraperitoneal injection, which would build the model of acute poisoning. Group B and C were treated by gavage with 3ml/kg and 10ml/kg of Xuebijing oral solution respectively, once a day to maintain. Group A were treated with saline instead.

Results

The analysis of survival curve showed that the survival rate was not significantly different between group A and B, but group C was significantly higher than group A and B(P<0.05).

Conclusion

Large doses of Xuebijing oral solution may improve the survival rate of acute paraquat poisoning.