Table 1

Characteristics of randomised controlled trials included in meta-analysis examining the effect of garlic on blood pressure

Source

Study design; Intervention/control groups

Type of garlic preparation, Dosage, Duration

Number of participants in intervention vs control group

Mean SBP (SD) at start/end of intervention vs control in mm Hg

Mean DBP (SD) at start/end of intervention vs control in mm Hg


Kandziora J 1988 (Study 1), [11]

Parallel,

Garlic powder (Kwai),

20/20

Garlic: 174 (4)/158 (10)

Garlic: 99 (3)/83 (4)

Diuretic drug (Dytide H) + garlic/drug only

600 mg/d,

(standing)

Control: 175 (8)/169 (6)

Control: 98 (5)/90 (3)

12 wks

Auer et al. 1990, [12]

Parallel,

Kwai,

24/23

Garlic: 171 (21.6)/152 (19.6)

Garlic: 102 (13)/89 (4.4)

Garlic/placebo

600 mg/d,

Control: 161 (19)/153 (19)

Control: 97 (12.9)/93 (10.6)

12 wks

Vorberg & Schneider 1990, [13]

Parallel,

Kwai,

20/20

Garlic: 144.5 (13.4)/138.5 (4.3)

Garlic: 91 (3.9)/87 (3.7)

Garlic/placebo

900 mg/d,

Control: 144 (10.4)/147 (7.1)

Control: 88 (6.1)/90 (3.7)

16 wks

Holzgartner et al. 1992, [14]

Parallel,

Kwai,

47/47

Garlic: 143.4 (15.4)/135.4 (14.6)

Garlic: 82.8 (10.5)/78.6 (9.3)

Lipid-lowering drug (Benzafibrate) + garlic/drug only

900 mg/d,

Control: 140.6 (18.7)/137.2 (14.6)

Control: 82.4 (9.5)/78.4 (9.2)

12 wks

Kiesewetter et al. 1993, [15]

Parallel,

Kwai,

32/32

Not reported

Garlic: 84.7 (13.7)/81.7 (12.1)

Garlic/placebo

800 mg/d,

Control: 83.3 (11)/81.7 (11)

12 wks,

Jain et al. 1993, [16]

Parallel,

Kwai,

20/22

Garlic: 129 (13)/130 (17)

Garlic: 82 (6)/81 (10)

Garlic/placebo

900 mg/d,

Control: 128 (10)/127 (12)

Control: 83 (8)/82 (6)

12 wks

Saradeth et al. 1994, [17]

Parallel,

Kwai,

25/27

Garlic: 125 (17)/127.4 (16)

Garlic: 80.8 (8)/82.7 (10)

Garlic/placebo

600 mg/d,

Control: 124.6 (15.6)/122.8 (12.5)

Control: 81.8 (9.4)/81.1 (9.4)

15 wks

Simons et al. 1995, [18]

Crossover,

Kwai,

28/28

Garlic: 127 (14)/119 (7)

Garlic: 80 (8)/76 (5)

Garlic/placebo

900 mg/d,

Control: 127 (14)/122 (10)

Control: 80 (8)/76 (6)

12 wks

Steiner et al. 1996, [19]

Parallel study arm,

Aged garlic extract,

41/41

Garlic: 134 (14)/126 (14)

Garlic: 84 (8.6)/82.3 (9)

Garlic/placebo

2400 mg/d,

Control: 134 (11)/129.6 (12)

Control: 85 (7.4)/81.7 (8)

23 wks

Adler & Holub 1997, [20]

Parallel,

Kwai,

12/13/10/11

Garlic: 123.3 (14.5)/118.5 (9.4)

Garlic: 83.2 (2.5)/80 (2.2)

Garlic/garlic+fish oil/fish oil/placebo

900 mg/d,

Control: 118.3 (3.2)/119.6 (3)

Control: 79.6 (2.2)/80.9 (2)

12 wks

Zhang et al. 2000, [21]

Parallel,

Distilled garlic oil,

14/13

Garlic: 117 (8)/113.5 (6.4)

Garlic: 72 (7)/68.2 (9.4)

Garlic/placebo

12.3 mg/d,

Control: 109 (9)/109.9 (9.4)

Control: 64 (7)/62.8 (5.4)

16 wks


SBP, systolic blood pressure; DBP, diastolic blood pressure; SD, standard deviation; vs, versus; mm Hg, millimetre mercury; mg/d, milligram per day; wks, weeks; mths, months.

Ried et al. BMC Cardiovascular Disorders 2008 8:13   doi:10.1186/1471-2261-8-13

Open Data