Table 3

Time effects on markers of subclinical atherosclerosis and anthropometric and cardiometabolic profiles
Modified intention-to-teat analysis (N = 92) Per-protocol analysis (N = 49)
Mean (SD) Pa Mean (SD) Pa
FMD (mm)
 3 M 10.93 (3.57) .676 11.23 (3.67) .628
 6 M 11.33 (3.84) 1171 (4.17)
 9 M 11.41 (4.20) 11.54 (4.57)
 12 M 11.11 (4.18) 10.93 (4.47)
PWV (m/sec)
 3 M 7.89 (1.14) .048 7.60 (0.87) .055
 6 M 7.72 (1.19) 7.36 (0.88)
 9 M 7.88 (1.19) 7.57 (1.00)
 12 M 7.87 (1.15) 7.56 (0.88)
IMT (mm)
 3 M 0.70 (0.16) .018†‡ 0.71 (0.19) .042
 6 M 0.67 (0.14) 0.67 (0.16)
 9 M 0.68 (0.13) 0.70 (0.13)
 12 M 0.69 (0.13) 0.71 (0.13)
Body weight (kg)
 3 M 70.45 (10.86) <.001*†‡ 67.84 (9.46) <.001*†‡
 6 M 68.95 (11.37) 65.81 (9.87)
 9 M 68.96 (11.41) 65.08 (7.84)
 12 M 69.04 (11.55) 66.03 (10.14)
Lean body mass (kg)
 3 M 45.29 (4.97) .040* 44.65 (5.01) .153
 6 M 45.14 (5.02) 44.40 (5.08)
 9 M 45.08 (4.96) 44.10 (4.29)
 12 M 44.99 (4.89) 44.28 (4.86)
WC (cm)
 3 M 92.80 ( 9.21) <.001*†‡ 89.88 (7.01) <.001†
 6 M 90.82 (10.10) 87.09 (7.95)
 9 M 90.85 (10.08) 87.14 (7.26)
 12 M 91.39 ( 9.81) 88.42 (7.60)
Systolic BP(mmHg)
 3 M 114.30 (15.41) .245 111.57 (12.21) .253
 6 M 112.77 (14.80) 110.03 (13.00)
 9 M 113.59 (14.18) 110.43 (10.65)
 12 M 113.08 (14.69) 109.57 (11.51)
TC (mg/dL)
 3 M 196.93 (38.15) .006 195.40 (42.20) .013
 6 M 196.73 (36.47) 192.33 (37.43)
 9 M 203.46 (38.37) 201.86 (41.14)
 12 M 199.39 (41.15) 194.66 (45.70)
LDL-C (mg/dL)
 3 M 118.64 (35.38) .020 118.13 (41.36) .034
 6 M 118.52 (31.52) 115.88 (34.15)
 9 M 123.07 (36.68) 121.74 (41.40)
 12 M 118.76 (38.17) 115.65 (43.25)
HDL-C (mg/dL)
 3 M 52.07 (11.78) <.001* 51.59 (12.63) <.001*
 6 M 54.01 (12.54) 53.97 (14.28)
 9 M 55.34 (12.25) 56.92 (13.64)
 12 M 56.47 (13.26) 57.59 (14.06)
Triglycerides (mg/dL)
 3 M 131.12 (77.41) .289 128.39 (90.15) .197
 6 M 121.00 (62.72) 112.40 (60.51)
 9 M 125.25 (71.84) 115.99 (77.68)
 12 M 120.55 (68.62) 106.64 (68.35)
Fasting glucose (mg/dL)
 3 M 90.65 (13.13) <.001 89.09 (9.52) .034*†
 6 M 87.42 (12.54) 85.13 (9.33)
 9 M 87.29 (14.41) 85.60 (13.13)
 12 M 89.62 (13.70) 88.23 (11.93)
VO2max (mL/kg/min)
 3 M 32.06 (5.27) <.001*†‡ 33.23 (4.34) <.001*†
 6 M 35.24 (6.44) 37.04 (4.63)
 9 M 35.14 (6.26) 37.05 (4.97)
 12 M 34.48 (6.21) 36.02 (5.15)

aP-values for an equality of mean values across periods; Significance of trend tests: *Linear trend, Quadratic trend, Cubic trend.

FMD = flow mediated dilation; PWV = pulse wave velocity; IMT = intima media thickness; HDL-C = high-density lipoprotein cholesterol; LDL-C = low-density lipoprotein cholesterol; SD = standard deviation; TC = total cholesterol; VO2max = maximal oxygen consumption; WC = waist circumference.

Choo et al.

Choo et al. BMC Cardiovascular Disorders 2014 14:82   doi:10.1186/1471-2261-14-82

Open Data