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Open Access Highly Accessed Research article

Association between serum uric acid levels and cardiovascular disease in middle-aged and elderly Chinese individuals

Li Qin1, Zhen Yang1, Hongxia Gu2, Shuai Lu2, Qun Shi2, Yin Xing2, Xiaoyong Li1, Rui Li3, Guang Ning4 and Qing Su1*

Author Affiliations

1 Department of Endocrinology, Xinhua hospital, School of medicine, Shanghai Jiaotong University, Kongjiang Road, Shanghai 1665, China

2 Department of Endocrinology, Xinhua hospital Chongming branch, School of medicine, Shanghai Jiaotong University, Shanghai, China

3 Shanghai Municipal Center For Disease Control And Prevention, Shanghai, China

4 Department of Endocrinology, Ruijin hospital, School of medicine, Shanghai Jiaotong University, Shanghai, China

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BMC Cardiovascular Disorders 2014, 14:26  doi:10.1186/1471-2261-14-26

Published: 25 February 2014

Abstract

Background

A link between uric acid (UA) levels and cardiovascular diseases has been previously reported. However, its importance as a risk factor is still controversial. This study sought to determine whether elevated serum uric acid levels are associated with cardiovascular disease (CVD) in middle-aged and elderly Chinese individuals.

Methods

We conducted a population-based cross-sectional study in Shanghai, with a total of 8510 participants aged ≥40 years. The CVD included diagnosed coronary heart disease (CHD) and stroke. MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans.

Results

Uric acid levels were positively associated with BMI, waist circumference, triglycerides, systolic blood pressure, diastolic blood pressure, glycohemoglobin, fasting plasma glucose, postprandial 2-hour plasma glucose (all P < 0.05), and negatively associated with HDL-cholesterol (P < 0.001). The prevalence of CVD significantly increased with increasing quartiles of UA in those without MetS group (p trend < 0.001), but not necessarily increased in those with MetS. After adjustment for metabolic syndrome and other cardiovascular risk factors, multivariate logistic regression analysis showed that odds ratios (OR) for CHD, stroke, and CVD in those in the fourth quartiles were 2.34 (95% confidence interval [CI] 1.73 to 3.45), 2.18 (95% CI 1.86 to 3.28), and 2.16 (95% CI 1.80 to 3.29), respectively, compared with those in the first quartile of UA.

Conclusions

Elevated serum uric acid level was associated with CVD, independent of conventional cardiovascular disease risk factors and metabolic syndrome.

Keywords:
Uric acid; Cardiovascular disease; Metabolic syndrome; Stroke; Coronary heart disease