Table 1

Randomized trials of beta blockers for the prevention of sudden cardiac death
Trial (Reference) Year Number of patients Name of drug Comparator Daily maintenance dose (mg) Follow-up (months) Jadad scoring
Anderson et al.12 1985 50 Metoprolol Control 61 19 3
ANZ16 1997 415 Carvedilol Placebo 12.5 19 4
BEST6 2001 2708 Bucindolol Placebo 152 24 5
BHAT39 1986 3837 Propranolol Placebo 180/240 25 5
Bristow et al.17 1994 139 Bucindolol Placebo 12.5/50/200 3 5
Bristow et al.18 1996 345 Carvedilol Placebo 12.5/25/50 6 5
Capricorn19 2001 1959 Carvedilol Placebo 50 15.6 5
CIBIS II21 1999 2647 Bisoprolol Placebo 10 15 5
CIBIS20 1994 641 Bisoprolol Placebo 5 23 5
CILICARD33 2000 124 Celiprolol Placebo 100 12 5
Colucci et al.22 1996 366 Carvedilol Placebo 100 15 5
COPERNICUS8 2002 2289 Carvedilol Placebo 50 10.4 5
De Milliano et al.34 2002 59 Metoprolol Placebo 150 6 5
ELANDD35 2011 116 Nebivelol Placebo 5/10 6 5
Engleimeir et al.23 1985 25 Metoprolol Placebo 92 12 4
Fisher et al.24 1994 50 Metoprolol Placebo 87 6 5
Hansteen V. et al.25 1982 560 Propranolol Placebo 160 12 5
Krum et al.26 1995 49 Carvedilol Placebo 50 4 5
MDC27 1993 383 Metoprolol Placebo 108/115 18 3
MERIT-HF28 1999 3991 Metoprolol Placebo 159/170 12 5
Metra et al.29 1994 40 Carvedilol Placebo 50 4 4
Olsen et al.30 1995 60 Carvedilol Placebo 81 4 5
Packer et al.31 1996 1094 Carvedilol Placebo 60 6 5
Pollock et al.32 1990 19 Bucindolol Placebo 200 3 4
RESOLVD36 2000 426 Metoprolol Placebo 156 6 5
SENIORS14 2005 2128 Nebivelol Placebo 7.7 21 5
Sturm37 2000 100 Atenolol Placebo 89 24 5
UHLIR et al.38a 1997 91 Nebivelol Placebo 2.5/5 3.5 5
Wisenbaugh et al.15 1993 24 Nebivelol placebo 5 3 5
Woodley et al.13 1991 50 Bucindolol Placebo 175 3 5

ANZ: Australian/New Zealand Heart Failure Research Collaborative Group; BEST: Beta-blocker Bucindolol in patients with advanced chronic heart failure; CAPRICORN: Effect of carvedilol on outcome after myocardial infarction inpatients; COPRINCUS: Effect of Carvedilol on the Morbidity of Patients with Severe chronic Heart Failure; MDC: Metoprolol in Dilated Cardiomyopathy Trial study; Merit-HF: Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure; SENIORS: Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure.

Al-Gobari et al.

Al-Gobari et al. BMC Cardiovascular Disorders 2013 13:52   doi:10.1186/1471-2261-13-52

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