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Association of cardiovascular response to an acute resistance training session with the ACE gene polymorphism in sedentary women: a randomized trial

Jéssica Cardoso de Souza14*, Ramires Alsamir Tibana1, Nuno Manuel Frade de Sousa2, Vinícius Carolino de Souza1, Margô G O Karnikowski3, Jonato Prestes1 and Carmen Silvia Grubert Campbell1

Author Affiliations

1 Graduation Program on Physical Education, Catholic University of Brasilia, Brasilia, Brazil

2 Graduation Program Inter-unities - Bioengineering, EESC/FMRP/IQSC, USP, Sao Carlos, Brazil

3 Graduation Program in Medical Sciences, University of Brasilia, Brasilia, Brazil

4 Physical Education Program, Catholic University of Brasilia, Q.S. 07, Lote 01, EPTC – Bloco G. Zip code: 71966-700 – Aguas Claras – Federal District, Brasilia, Brazil

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BMC Cardiovascular Disorders 2013, 13:3  doi:10.1186/1471-2261-13-3

Published: 10 January 2013



The aim of the present study was to verify the effects of an acute resistance training (RT) session and insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) on systolic (SBP), diastolic (DBP) and mean blood pressure (MBP), and heart rate (HR).


The sample consisted of 27 sedentary women (33.3 ± 8.2 yrs; 69.1 ± 13.8 kg; 1.57 ± 0.05 m; 27.6 ± 5.1 kg/m2) divided into two groups according to their polymorphism I/D (DD = 9; II + ID = 18). Volunteers underwent two experimental sessions: RT – an acute session performed with three sets at 60% of one-repetition maximum (1RM) interspersed with 1 minute rest interval between exercises and sets, and a control session (CON) in which they remained seated for 30 minutes in the laboratory. SBP, DBP, MBP and HR were measured before exercise and during one hour every 10 minutes after sessions, in the seated position. A two-way ANOVA for repeated measures with Tukey’s post hoc test was used for the intra and inter-group comparisons.


There were no statistically significant differences on SBP, DBP and MBP after the experimental protocols, and no effect of ACE polymorphism (P > 0.05). However, comparing CON versus exercise effect size values (ES), homozygotic carriers of the allele D presented a drop in SBP which was considered moderate, while in allele I carriers it was small, 30 minutes after exercise. In MBP, homozygotic D carriers exhibited a large ES 20 minutes post-exercise. HR was higher at 10, 20 and 30 minutes after exercise as compared to pre-exercise only for carriers of the I allele (P < 0.05).


Therefore, an acute RT session reduces clinical BP. In addition to this; it seems that ACE polymorphism had some influence on cardiovascular response to exercise.

Trial Registration


Resistance training; Blood pressure; Heart rate; Polymorphism; Angiotensin converting enzyme