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The REFER (REFer for EchocaRdiogram) protocol: a prospective validation of a clinical decision rule, NT-proBNP, or their combination, in the diagnosis of heart failure in primary care. Rationale and design

Lynda Tait, Andrea K Roalfe, Jonathan Mant, Martin R Cowie, Jonathan J Deeks, Rachel Iles, Pelham M Barton, Clare J Taylor, Marites Derit and FD Richard Hobbs*

BMC Cardiovascular Disorders 2012, 12:97  doi:10.1186/1471-2261-12-97