|Summary of RCTs included in the meta-analysis|
|First author/Year of publication||No. of subjects||Surgery type||CABG technology||TEA continued postoperatively||TEA||Perioperative management of TEA||Primary endpoint?||POAF||Study design/Jadad score|
|TEA + GA||GA|
|Jidéus/2001 ||121||elective CABG||CPB||Unclear||T2-T5, the day before surgery||Intraoperative: bupivacaine 5 mg/mL, with an infusion rate of 4 to 8 mL/h. Postoperative: continuous infusion of bupivacaine (2 mg/mL) and sufentanil (1 mg/mL) epidurally (3 to 7 mL/h)||Yes||13/41||29/80||RCT/2|
|Nygard/2004 ||163||elective CABG||CPB||4 days||T1-T3, the day before surgery||Intraoperative and postoperative : bolus doses of 4 mL of bupivacaine, 5 mg/mL, given hourly||Yes||28/79||25/84||RCT/3|
|Bakhtiary/2007 ||132||elective CABG||OPCAB||3 days||T1-T3, the day before surgery||Preoperative and postoperative: continuous infusion with ropivacaine 0.16 % and sufentanil 1 g/mL at an hourly rate of 2 to 5 mL was started after a bolus dose of 6 mL||Yes||2/66||18/66||RCT/2|
|Tenenbein/2008 ||50||elective or semi-elective CABG||CPB||2 days||T2-T5, at least four hours prior to systemic heparinization||Intraoperative: 5-mL bolus of 0.75% ropivacaine and 200 μg of hydromorphone in the epidural catheter, followed by infusion of 0.75 % ropivacaine at 5 mL/h. Postoperative: continuous infusion lasting 48 h and consisting of 0.2 % ropivacaine, with 15 μg/mL of hydromorphone titrated.||No||6/25||9/25||RCT/3|
|Caputo/2009 ||74||elective CABG||OPCAB||3 days||T2-T4, before induction of anesthesia||Intraoperative and postoperative: continuous infusion of 0.125 % bupivacaine and 0.0003 % clonidine (150 g in 500 mL) at an initial rate of 10 mL/h||No||7/36||18/38||RCT/3|
CABG, coronary artery bypass surgery; OPCAB, off-pump coronary artery bypass grafting; CPB, cardiopulmonary bypass; TEA, thoracic epidural anesthesia; GA, general anesthesia; POAF, postoperative atrial fibrillation; RCT, randomized controlled trial.
Gu et al.
Gu et al. BMC Cardiovascular Disorders 2012 12:67 doi:10.1186/1471-2261-12-67