The higher exercise intensity and the presence of allele I of ACE gene elicit a higher post-exercise blood pressure reduction and nitric oxide release in elderly women: an experimental study
- Equal contributors
1 Programa de Pós-graduação em Educação Física e Saúde, Universidade Católica de Brasília - UCB, Brasília-DF, Brazil
2 Centro Universitário do Planalto de Araxá - UNIARAXÀ; Araxá-MG, Brazil
3 Universidade Federal do Vale do São Francisco -UNIVASF- Petrolina-PE, Brazil
4 Faculdade de Educação Física do Centro Anhanguera Educacional, Taguatinga-DF, Brazil
5 Faculdade de Educação Física do Centro Universitário - UNIRG -, Gurupi-TO, Brazil
6 Instituto de Genética e Bioquímica da Universidade Federal de Uberlândia - UFU, Uberlândia-MG, Brazil
7 Programa de Pós-Graduação em Ciências Médicas e Programa de Pós -graduação em Ciências da Saúde, Universidade de Brasília - UnB, Brasília-DF, Brazil
BMC Cardiovascular Disorders 2011, 11:71 doi:10.1186/1471-2261-11-71Published: 2 December 2011
The absence of the I allele of the angiotensin converting enzyme (ACE) gene has been associated with higher levels of circulating ACE, lower nitric oxide (NO) release and hypertension. The purposes of this study were to analyze the post-exercise salivary nitrite (NO2-) and blood pressure (BP) responses to different exercise intensities in elderly women divided according to their ACE genotype.
Participants (n = 30; II/ID = 20 and DD = 10) underwent three experimental sessions: incremental test - IT (15 watts workload increase/3 min) until exhaustion; 20 min exercise 90% anaerobic threshold (90% AT); and 20 min control session without exercise. Volunteers had their BP and NO2- measured before and after experimental sessions.
Despite both intensities showed protective effect on preventing the increase of BP during post-exercise recovery compared to control, post-exercise hypotension and increased NO2- release was observed only for carriers of the I allele (p < 0.05).
Genotypes of the ACE gene may exert a role in post-exercise NO release and BP response.