Table 3

Comparison of NSE levels to predict poor outcome after cardiac arrest and referenced study profiles

Référence

In-hospital CPR (%)

Time of inclusion after CPR,

n

Hypothermic therapy,

n

Follow-up

Poor outcome definition, and number

n

Method used for NSE measurement

NSE sampling time

Cut-off value (ng/mL)

Se

Sp


Fogel et al.

[10] 1997

Not specified

ICU admission

n = 43

No

3 months

Remained comatose

n = 25

Radioimmunoassay, Pharmacia LKB

Day 0

Day 1

Day 2

Day 3

33

33

33

33

25

60

63

65

100

100

100

100


Martens et al.

[21] 1998

Not specified

> 24 h

n = 64

No

6 months

Remained comatose

n = 35

Radioimmunoassay, Profilogen

24 h

20

51

89


Schoerkhber et al. [11] 1999

Yes (not specified)

> 6 h

n = 56

No

6 months

CPC 3-5

n = 28

Radioimmunoassay, Profilogen

12 h

24 h

48 h

72 h

Peak NSE level 12-72 h

38

40

25

17

27

18

8

48

70

29

100

100

100

100

100


Rosen et al.

[12] 2001

No

> 24 h

n = 66

No

1 year

CPC 3-5

n = 42

Imunoluminometric assay, Byk Sangtec Diagnostica

Day1

Day2

Day3

25

25

25

NM

NM

NM

100

100

100


Zingler et al.

[15]2003

Yes (not specified)

ICU admission

n = 27

No

3 months

CPC 4-5

n = 17

Immunoluminometric assay, Byk Sangtec Diagnostica

Day1

Day2

Day3

Day7

48

43

91

39

53

91

75

57

100

100

100

100


Tiainem et al.

[14] 2003

No*

ICU admission

n = 70

Yes

n = 36

6 months

CPC 3-5

n = 29

time-resolved immunofluorometric assay (DELFIA, Wallac)

24 h HT/no HT

36 h HT/no HT

48 h HT/no HT

31/13

26/13

25/9

22/59

30/63

25/76

96/100

96/100

96/100


Meynaar et al.

[13] 2003

Yes (23%)

ICU admission

n = 110

No

Hospital

discharge

Remained comatose

n = 81

time-resolved immunofluorometric assay (DELFIA, Wallac)

Peak NSE level 24-48 h¶

25

59

100


Pfeifer et al.

[16]2005

Yes (44%)

> 48 h

n = 97

Not specified

Day 28

CPC 4-5

n = 70

Imunoluminometric assays, Byk Sangtec Diagnostica

Day 3

65

50

96


Rech at al.

[17]2006

Yes (100%)

>12 h

n = 45

No

6 months

CPC 4-5

n = 34

Electrochemiluminescence immunoassay, Roche Mannheim

Between 12-36 h

60

35

100


Zandbergen et al

[2]2006

Not specified

> 24 h

n = 407

Yes (not specified)

1 months

CPC 4-5

n = 356

Immunoluminometric assay, Byk Sangtec Diagnostica

24 h

48 h

72 h

>33

>33

>33

42

52

46

100

100

100


Auer et al.

[18] 2006

Yes (not specified)

n = 17

Not specified

Hospital

discharge

Death

n = 9

Electrochemiluminescence immunoassay, Roche Mannheim

48 h

30

79

100


Grubb et al.

[23] 2007

No

ICU admission

n = 143

Not specified

Hospital

discharge

Death

Enzyme immunoassay, Roche Diagnostics

12 h

24-48 h

72-96 h

NM

71

NM

14

100


Reisinger et al.

[19]2007

Yes (44%)

ICU admission

n = 177

Yes

n = 20

6 months

CPC 4-5

n = 59

Electrochemiluminescence immunoassay, Roche Mannheim

Peak NSE level

Day 0-4

80

63

100


Oksanen et al.

[20] 2009

No*

ICU admission

n = 90

Yes

n = 90

6 months

CPC 3-5

n = 40

Electrochemiluminescence immunoassay, Roche Mannheim

24 h

48 h

41

33

20

43

100

100


Rundgren et al.

[9] 2009

Yes (17%)

ICU admission

n = 102

(for NSE cohort)

Yes

n = 102

6 months

CPC 3-5

n = 46

Imunoluminometric assay, DiaSorin

2 h

24 h

48 h

72 h

31

38

28

27

6

11

67

50

100

100

100

100


Shinozaki et al.

[22] 2009

Yes (27%)

ICU admission

n = 80

Yes

n = 45

6 months

CPC 3-5

n = 67

Immunoradiometric assay, Profilogen, DiaSorin

Admission

6 h

24 h

46

66

40

14

19

72

100

100

100


Steffen et al

[42] 2010

Yes (21%)

ICU admission

n = 240

Yes

n = 133

ICU discharge

CPC 3-5

n = 147

Electrochemiluminescence immunoassay, Roche Mannheim

72 h HT/no HT

79/27

50

80

100

100


Present study

Yes (31%)

> 48 h

n = 97

Yes

n = 65

3 months

CPC 4-5

n = 72

Electrochemiluminescence immunoassay, Roche Mannheim

Peak NSE level 24-72 h

97

49

100


HT; hypothermic therapy, NM; not mentioned

* Only ventricular fibrillation as initial rhythm was eligible for the study

Results mentioned only for patients who remained comatose 48 hours after CPR (n = 67)

Daubin et al. BMC Cardiovascular Disorders 2011 11:48   doi:10.1186/1471-2261-11-48

Open Data