Table 2

Linear regression models predicting Lp-PLA2 mass (ng/mL)

Race & Sex (Model 1)

Model 1 + Biological Covariates

Model 1 + Lifestyle Covariates

Model 1 + SNPs*

All Covariates

Variables

β

P-value

β

P-value

β

P-value

β

P-value

β

P-value


Race

African-American

-55.0

< 0.0001

-50.2

< 0.0001

-57.2

< 0.0001

-49.6

< 0.0001

-47.3

< 0.0001

Hispanic

-26.2

0.0016

-25.8

0.0008

-30.1

0.001

-27.7

0.0008

-30.0

0.0004

Asian

-47.1

< 0.0001

-45.7

< 0.0001

-45.4

< 0.0001

-43.1

< 0.0001

-42.0

< 0.0001

Female gender

-24.2

< 0.0001

-18.5

0.0045

-24.5

< 0.0001

-22.8

< 0.0001

-18.4

0.011

Biological Covariates

Age (years)

2.4

0.0016

2.6

0.0019

Diabetes mellitus

-0.0042

0.95

-0.018

0.81

History of hypertension

-3.0

0.53

-3.76

0.49

Systolic blood pressure (mmHg)

0.16

0.23

0.14

0.33

Body mass index (kg/m2)

-0.46

0.63

-0.063

0.95

Waist circumference (cm)

0.092

0.81

-0.026

0.95

LDL (mg/dL)

0.75

< 0.0001

0.75

< 0.0001

HDL (mg/dL)

-0.26

0.094

-0.27

0.11

ADMA§ (μmol/L)

38.8

0.06

33.2

0.14

C-reactive protein (mg/L)

1.1

0.0017

1.1

0.002

Lifestyle/Demographic Covariates

Current smoking

0.012

0.90

0.0058

0.95

Exercise (kCal/kg-day)

0.63

0.40

0.76

0.28

% Calories from saturated fat

0.081

0.94

-0.96

0.38

% Calories from carbohydrates

-0.43

0.20

-0.60

0.058

Annual income ≥ $50,000

-0.019

0.74

0.051

0.32

College graduate

-0.091

0.086

-0.071

0.15

SNPs

Ala379Val

2.2

0.60

2.5

0.55

Arg92His

11.8

0.0023

11.6

0.0025

Ile198Thr

-8.8

0.19

-6.1

0.37


* SNPs, single nucleotide polymorphisms

Compared to White race

Compared to Male

§ADMA, asymmetric dimethylarginine

Lee et al. BMC Cardiovascular Disorders 2011 11:38   doi:10.1186/1471-2261-11-38

Open Data