Table 3

Parametric comparisons of cardiac parameters after 4 weeks of exposure to isoproterenol and treatment with P188 in BL10 and mdx mice.

Measurement

Group

N

Mean ± SD

Overall p-value

Significantly different groups


SF%

BL10 - Untx

3

33.34 ± 1.15

BL10-Untx vs. BL10-Iso (p = 0.019)

BL10-Untx vs. MDX-Iso+P188 (p = 0.017)


BL10 - Iso

7

45.13 ± 4.71

BL10-Iso vs. MDX-Untx (p < 0.001)


MDX - Untx

6

29.64 ± 3.11

<0.0001

BL10-Iso vs. MDX-Iso (p = 0.006)


MDX - Iso

9

35.37 ± 5.77

MDX-Untx vs. MDX-Iso+P188 (p < 0.001)


MDX - Iso + P188

5

45.97 ± 6.23

MDX-Iso vs. MDX-Iso+P188 (p = 0.007)


EF%

BL10 - Untx

3

59.15 ± 1.89


BL10 - Iso

7

69.72 ± 5.56


MDX - Untx

6

57.25 ± 7.78

0.0027

BL10-Iso vs. MDX-Untx (p = 0.020)


MDX - Iso

9

57.84 ± 4.56

BL10-Iso vs. MDX-Iso (p = 0.013)


MDX - Iso + P188

5

68.28 ± 9.89


LVID (d) (mm)

BL10 - Untx

3

4.03 ± 0.12


BL10 - Iso

7

3.73 ± 0.13

BL10-Untx vs. MDX-Iso+P188 (p = 0.002)


MDX - Untx

6

4.02 ± 0.07

0.0001

BL10-Iso vs. MDX-Iso (p = 0.029)


MDX - Iso

9

3.54 ± 0.34

MDX-Untx vs. MDX-Iso (p = 0.0125)


MDX - Iso + P188

5

3.27 ± 0.32

MDX-Untx vs. MDX-Iso+P188 (p < 0.001)


LVPW (d) (mm)

BL10 - Untx

3

0.62 ± 0.10


BL10 - Iso

7

0.80 ± 0.08

BL10-Untx vs. BL10-Iso (p = 0.022)


MDX - Untx

6

0.59 ± 0.01

<0.0001

BL10-Untx vs. MDX-Iso (p = 0.001)

BL10-Untx vs. MDX-Iso+P188 (p = 0.004)


MDX - Iso

9

0.86 ± 0.09

BL10-Iso vs. MDX-Untx (p < 0.001)


MDX - Iso + P188

5

0.84 ± 0.07

MDX-Untx vs. MDX-Iso (p < 0.001) MDX-Untx vs. MDX-Iso+P188 (p < 0.001)


LV mass (mg)

BL10 - Untx

3

75.16 ± 7.16


BL10 - Iso

7

98.33 ± 11.06


MDX - Untx

6

76.88 ± 3.36

0.0019

BL10-Untx vs. BL10-Iso (p = 0.012)


MDX - Iso

9

87.22 ± 11.08

BL10-Iso vs. MDX-Untx (p = 0.003)


MDX - Iso + P188

5

89.15 ± 7.54


AoV vel (mm/s)

BL10 - Untx

3

1004 ± 87


BL10 - Iso

7

1077 ± 186


MDX - Untx

6

1105 ± 117

0.0388

None


MDX - Iso

9

1274 ± 159


MDX - Iso + P188

5

1253 ± 183


Systolic BP (mmHg)

BL10 - Untx

3

94 ± 5


BL10 - Iso

7

99 ± 8

BL10-Untx vs. MDX-Iso (p = 0.011)


MDX - Untx

3

87 ± 8

0.0001

BL10-Iso vs. MDX-Iso (p < 0.001)


MDX - Iso

9

73 ± 11

BL10-Iso vs. MDX-Iso+P188 (p = 0.006)


MDX - Iso + P188

4

77 ± 6


Diastolic BP (mmHg)

BL10 - Untx

3

50 ± 9


BL10 - Iso

7

85 ± 8


MDX - Untx

3

67 ± 3

<0.0001

BL10-Untx vs. BL10-Iso (p < 0.001)

BL10-Iso vs. MDX-Untx (p = 0.022)


MDX - Iso

9

61 ± 8

BL10-Iso vs. MDX-Iso (p < 0.001)


MDX - Iso + P188

4

58 ± 3

BL10-Iso vs. MDX-Iso+P188 (p < 0.001)


Mean BP (mmHg)

BL10 - Untx

3

64 ± 7


BL10 - Iso

7

89 ± 7

BL10-Untx vs. BL10-Iso (p < 0.001)


MDX - Untx

3

73 ± 4

<0.0001

BL10-Iso vs. MDX-Untx (p = 0.018)


MDX - Iso

9

63 ± 7

BL10-Iso vs. MDX-Iso (p < 0.001)


MDX - Iso + P188

4

64 ± 2

BL10-Iso vs. MDX-Iso+P188 (p < 0.001)


SF% - shortening fraction percent; EF% - ejection fraction percent; LVID(d) - left ventricular internal diameter in diastole; LVPW(d) - left ventricular posterior wall thickness in diastole; LV - left ventricle; AoV vel - aortic valve velocity; BP - blood pressure; mmHg - millimeters of mercury; SD - standard deviation; mm - millimeters; mm/s - millimeters per second; mg - milligrams; iso - isoproterenol; untx - untreated

Spurney et al. BMC Cardiovascular Disorders 2011 11:20   doi:10.1186/1471-2261-11-20

Open Data