Table 2

Parametric comparisons of cardiac parameters after 2 weeks of exposure to isoproterenol and treatment with P188 in BL10 and mdx mice.

Measurement

Group

N

Mean ± SD

Overall p-value

Significantly different groups


SF%

BL10 - Untx

3

31.47 ± 0.56

BL10-Untx vs. BL10-Iso (p < 0.001)


BL10 - Iso

7

49.33 ± 3.87

<0.0001

BL10-Untx vs. MDX-Iso+P188 (p = 0.001)

BL10-Iso vs. MDX-Untx (p < 0.001)


MDX - Untx

6

30.31 ± 2.50

BL10-Iso vs. MDX-Iso (p < 0.001)


MDX - Iso

10

38.06 ± 4.81

BL10-Iso vs. MDX-Iso+P188 (p = 0.019)


MDX - Iso + P188

9

42.95 ± 3.27

MDX-Untx vs. MDX-Iso (p = 0.003)

MDX-Untx vs. MDX-Iso+P188 (p < 0.001)


LVID (d) (mm)

BL10 - Untx

3

4.07 ± 0.35


BL10 - Iso

7

3.70 ± 0.14


MDX - Untx

6

3.84 ± 0.27

0.0011

BL10-Untx vs. MDX-Iso+P188 (p = 0.007)

MDX-Untx vs. MDX-Iso+P188 (p = 0.030)


MDX - Iso

10

3.42 ± 0.37


MDX - Iso + P188

9

3.37 ± 0.22


LVPW (d) (mm)

BL10 - Untx

3

0.56 ± 0.01

BL10-Untx vs. BL10-Iso (p = 0.001)


BL10 - Iso

7

0.85 ± 0.07

BL10-Untx vs. MDX-Iso (p = 0.001)


MDX - Untx

6

0.60 ± 0.09

<0.0001

BL10-Untx vs. MDX-Iso+P188 (p < 0.001)

BL10-Iso vs. MDX-Untx (p = 0.001)


MDX - Iso

10

0.88 ± 0.14

MDX-Untx vs. MDX-Iso (p < 0.001)


MDX - Iso + P188

9

0.94 ± 0.07

MDX-Untx vs. MDX-Iso+P188 (p < 0.001)


LV mass (mg)

BL10 - Untx

3

77.48 ± 1.60

BL10-Untx vs. BL10-Iso (p = 0.002)


BL10 - Iso

7

105.7 ± 12.22

BL10-Iso vs. MDX-Untx (p < 0.001)


MDX - Untx

6

73.16 ± 9.55

<0.0001

BL10-Iso vs. MDX-Iso (p < 0.001)


MDX - Iso

10

81.84 ± 9.62

BL10-Iso vs. MDX-Iso+P188 (p = 0.003


MDX - Iso + P188

9

85.26 ± 9.21


AoV vel (mm/s)

BL10 - Untx

3

1107 ± 49


BL10 - Iso

7

1194 ± 152

BL10-Iso vs. MDX-Iso (p = 0.003)


MDX - Untx

6

943 ± 67

<0.0001

MDX-Untx vs. MDX-Iso+P188 (p = 0.001)


MDX - Iso

10

885 ± 195

MDX-Iso vs. MDX-Iso+P188 (p < 0.001)


MDX - Iso + P188

9

1317 ± 150


Systolic BP (mmHg)

BL10 - Untx

3

92 ± 6


BL10 - Iso

7

107 ± 5

BL10-Iso vs. MDX-Untx (p = 0.023)


MDX - Untx

3

88 ± 3

0.0005

BL10-Iso vs. MDX-Iso (p < 0.001)


MDX - Iso

5

82 ± 5

BL10-Iso vs. MDX-Iso+P188 (p = 0.031)


MDX - Iso + P188

6

92 ± 13


SF% - shortening fraction percent; LVID(d) - left ventricular internal diameter in diastole; LVPW(d) - left ventricular posterior wall thickness in diastole; LV - left ventricle; AoV vel - aortic valve velocity; BP - blood pressure; mmHg - millimeters of mercury; SD - standard deviation; mm - millimeters; mm/s - millimeters per second; mg - milligrams; iso - isoproterenol; untx - untreated

Spurney et al. BMC Cardiovascular Disorders 2011 11:20   doi:10.1186/1471-2261-11-20

Open Data