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Open Access Highly Accessed Research article

Distribution, size, shape, growth potential and extent of abdominal aortic calcified deposits predict mortality in postmenopausal women

Mads Nielsen12*, Melanie Ganz12, Francois Lauze1, Paola C Pettersen3, Marleen de Bruijne14, Thomas B Clarkson5, Erik B Dam2, Claus Christiansen6 and Morten A Karsdal6

Author Affiliations

1 Department of Computer Science, University of Copenhagen, Copenhagen, Denmark

2 Nordic Bioscience Imaging A/S, Herlev, Denmark

3 CCBR Synarc, Ballerup, Denmark

4 Biomedical Imaging Group Rotterdam, Department of Radiology, Erasmus MC, Rotterdam, the Netherlands

5 Wake Forest University School of Medicine, Winston-Salem, NC, USA

6 Nordic Bioscience A/S, Herlev, Denmark

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BMC Cardiovascular Disorders 2010, 10:56  doi:10.1186/1471-2261-10-56

Published: 10 November 2010

Abstract

Background

Aortic calcification is a major risk factor for death from cardiovascular disease. We investigated the relationship between mortality and the composite markers of number, size, morphology and distribution of calcified plaques in the lumbar aorta.

Methods

308 postmenopausal women aged 48-76 were followed for 8.3 ± 0.3 years, with deaths related to cardiovascular disease, cancer, or other causes being recorded. From lumbar X-rays at baseline the number (NCD), size, morphology and distribution of aortic calcification lesions were scored and combined into one Morphological Atherosclerotic Calcification Distribution (MACD) index. The hazard ratio for mortality was calculated for the MACD and for three other commonly used predictors: the EU SCORE card, the Framingham Coronary Heart Disease Risk Score (Framingham score), and the gold standard Aortic Calcification Severity score (AC24) developed from the Framingham Heart Study cohorts.

Results

All four scoring systems showed increasing age, smoking, and raised triglyceride levels were the main predictors of mortality after adjustment for all other metabolic and physical parameters. The SCORE card and the Framingham score resulted in a mortality hazard ratio increase per standard deviation (HR/SD) of 1.8 (1.51-2.13) and 2.6 (1.87-3.71), respectively. Of the morphological x-ray based measures, NCD revealed a HR/SD >2 adjusted for SCORE/Framingham. The MACD index scoring the distribution, size, morphology and number of lesions revealed the best predictive power for identification of patients at risk of mortality, with a hazard ratio of 15.6 (p < 0.001) for the 10% at greatest risk of death.

Conclusions

This study shows that it is not just the extent of aortic calcification that predicts risk of mortality, but also the distribution, shape and size of calcified lesions. The MACD index may provide a more sensitive predictor of mortality from aortic calcification than the commonly used AC24 and SCORE/Framingham point card systems.