Open Access Research article

Evaluation of the consequences associated with diffuse vascular disease history in patients diagnosed with peripheral arterial disease: estimates from Saskatchewan health data

Kristen Migliaccio-Walle1, Michael Stokes2*, Irina Proskorovsky2, Dan Popovici-Toma3 and Wissam El-Hadi4

Author Affiliations

1 United BioSource Corporation, Lexington, MA, USA

2 United BioSource Corporation, Montréal, QC, Canada

3 sanofi-aventis Canada Inc., Laval, QC, Canada

4 Bristol-Myers Squibb Canada, St-Laurent, QC, Canada

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BMC Cardiovascular Disorders 2010, 10:40  doi:10.1186/1471-2261-10-40

Published: 2 September 2010



Peripheral arterial disease (PAD) is caused by narrowing of the arteries in the lower extremities. Limited data exist concerning the impact of diffuse vascular disease (DVD) on prognosis and costs. Thus, the objective of this study is to estimate the impact of DVD on morbidity, mortality and costs.


PAD was identified between 1985 and 1995 and classified by extent of DVD at diagnosis: none (PAD only, reference group), prior myocardial infarction (MI), prior stroke, prior MI and stroke (MI + stroke), prior transient ischemic attack (TIA). Deaths and hospitalizations were identified through December 2000. Hospitalization costs were estimated from the Ontario Case Cost Project, reported in 2002 $CAD. Proportional hazards analyses measured the impact of vascular involvement on mortality while controlling for risk factors (e.g., age, cardiovascular history).


Overall, 16,439 patients with PAD were included; 14.8% had a prior MI, 10.2% a prior stroke, 2.6% prior MI + stroke, 6.4% prior TIA, two-thirds had PAD only. Median survival was shorter for patients with prior MI (9.3 yrs), TIA (6.3), stroke (4.7), and MI+stroke (4.1) versus the reference group (9.9, p < 0.05, all comparisons). Analyses revealed that the death risk was 60% higher in patients with prior stroke and 84% higher for MI + stroke. Atherothrombotic and bleeding event-related costs were $712, $337, $268, and $170 higher per patient/year of follow-up in patients with a history of MI+stroke, MI, stroke, and TIA, respectively.


Patients diagnosed with PAD with DVD have higher risk of poor outcomes and increased costs.