Table 3 |
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|
Pharmacokinetic parameter estimates of remifentanil in pediatric patients undergoing cardiac surgery. |
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|
This studya |
Pediatricb |
Adultsc |
Adultsc |
Pediatricb |
Adultsd |
|||
|
Pre-CPB |
CPB |
Post-CPB |
Pre-CPB |
CPB |
Post-CPB |
|||
|
|
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|
Volumes (mL/kg) |
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|
Vc |
124 |
298 |
298 |
72.7 |
41.8 (23–61) |
65.9 (22.6–89.0) |
83.5 |
22.6 |
|
Vdss |
124 |
298 |
298 |
235 |
1006 (245–1767) |
344 (246–456) |
235 |
456 |
|
Clearances (mL/min/kg) |
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|
CL |
21.4 |
21.4 |
21.4 |
38.7 |
32.5 (32–33) |
31 (25–35) |
46.8 |
33 |
|
Q |
N.A. |
N.A. |
N.A. |
25.5 |
29.6 (28.7–30.5) |
39.8 (28.7–51.2) |
37.0 |
28.7 |
|
Half-lives (min) |
||||||||
|
Distribution |
N.A. |
N.A. |
N.A. |
0.73 |
0.43 (0.25–0.6) |
0.55 (0.25–0.8) |
0.63 |
0.25 |
|
Elimination |
4.02 |
9.65 |
9.65 |
8.2 |
8.35 (6.4–10.3) |
13.0 (7.2–19.8) |
6.90 |
19.8 |
|
|
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|
Abbreviations: CPB = cardiopulmonary bypass; Vc = central volume of distribution; Vdss = volume of distribution at steady-state; CL = clearance; Q = intercompartmental clearance, N.A. = not applicable a Values are presented as population mean b Values are presented as mean as reported by Davis et al [3] c Values are presented as mean (range) values as reported by Michelsen et al and Russel et al [12,13] d Values are presented as mean as reported by Michelsen et al [12] |
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|
Sam et al. BMC Anesthesiology 2009 9:5 doi:10.1186/1471-2253-9-5 |
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