Table 3

Summary of the economic studies identified in the literature (values in US$). Results in all patients and by severity subgroups when available, drotrecogin alfa compared to placebo

Study Country (year of publication)

Incremental Cost*

Incremental * effectiveness (LYG)

ICER* All severe sepsis patients

ICER* Higher risk patients


Manns et al. [40]

Canada (2002)

-

0.38 LYG

0.76 LYG (APACHE II ≥ 25)

$ 27,936/LYG

$ 19,726/LYG (APACHE II ≥ 25)

Neilson et al [39]

Germany (2003)

$10,533 (all patients)

$11,238 LYG (≥ 2 organ dysfunctions)

0.47 LYG

0.69 LYG (≥ 2 organ dysfunctions)

US$ 22,411/LYG (3% discounting)

$ 17,419/LYG (≥ 2 organ dysfunctions)

Angus et al. [41]

US (2003)

$16,000 (±4,200) (all patients)

0.48 LYG (SD 0.29) (all patients)

$ 33,300/LYG

-

Betancourt et al [38]

US (2003)

$6,246 (all patients)

$6,246 (≥ 2 organ dysfunctions)

0.06 lives saved**

0.08 (≥ 2 organ dysfunctions)

$ 104,100/life saved**

$78,075/life saved (≥ 2 organ dysfunctions)**

Fowler et al. [34]

Canada (2003)

$10,745 (all patients)

$15,166 (APACHE ≥ 25)

0.68 LYG

1.4 LYG (APACHE ≥ 25)

$ 15,801/LYG

$ 10,833/LYG (APACHE ≥ 25)

Riou França et al. [35]

France (2006)

$7,545 (all patients)

$7,333 (2 organ dysfunctions)

0.64 LYG (all patients)

0.57 (2 organ dysfunctions)

$ 11,812/LYG

$12,942/LYG (2 organ dysfunctions)

Hjelmgren et al [36]

Sweden (2005)

$12,272 (all patients)

$14,663 (≥ 2 organ dysfunctions)

0.544 LYG

0.474 LYG (≥ 2 organ dysfunctions)

US$ 22,920/LYG

$ 30,853/LYG (≥ 2 organ dysfunctions)

Davies et al. [37]

UK (2005)

Using PROWESS data

$9,517

1.12 LYG

US$ 8,533/LYG

-

Green et al. [42]

UK (2006)

$11,645 (SD $1,098) (all patients)

$12,336 (SD $1,430) (≥ 2 organ dysfunctions)

1.144 LYG (SD 0.34)

1.351 LYG (≥ 2 organ dysfunctions)

$ 10,176/LYG

$ 9,132/LYG (≥ 2 organ dysfunctions)


LYG = life-year gained/SD = standard deviation/TA = technology assessment

*Results comparing drotrecogin alfa to placebo

** $/LYG not available.

Costa and Brophy BMC Anesthesiology 2007 7:5   doi:10.1186/1471-2253-7-5

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